Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-11-04
1993-01-12
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514382, 514473, 548251, 548252, 548253, 549480, 549483, 549484, 549478, 549497, 549498, 549504, C07D30734, A61K 3134
Patent
active
051791234
ABSTRACT:
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxgen, sulfur, --CH.dbd.CH--or --CH.dbd.N--; wherein R.sub.1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is --CO.sub.2 R.sup.2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R.sup.3 is hydroxyl or halogen, having utility as LTB.sub.4 synthesis inhibitors.
REFERENCES:
patent: 4015010 (1977-03-01), Houlihan et al.
patent: 4469885 (1984-09-01), Mueller et al.
Djuric Stevan W.
Haack Richard A.
Miyashiro Julie M.
Davis Zinna N.
G. D. Searle & Co.
Ivy C. Warren
Matukaitis Paul D.
Williams Roger A.
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