Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-12-18
1992-02-04
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
562459, 562463, 562473, 562474, 562475, 560 51, 560 53, 560 65, 560 67, 564 92, 564 99, 514568, 514604, 514605, 548252, 548253, C07C 6532
Patent
active
050860674
ABSTRACT:
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CH.dbd.CH-- or --CH.dbd.N--; wherein R.sub.1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is --CO.sub.2 R.sup.2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R.sup.3 is hydroxyl or halogen, having utility as LTB.sub.4 synthesis inhibitors.
REFERENCES:
patent: 3255241 (1966-06-01), Schultz et al.
patent: 3912656 (1975-10-01), Andrews et al.
patent: 3919250 (1975-11-01), Pauling
patent: 4015010 (1977-03-01), Houlihan et al.
patent: 4469885 (1984-09-01), Mueller et al.
Djuric Stevan W.
Haack Richard A.
Miyashiro Julie M.
G. D. Searle & Co.
Ivy C. Warren
Matukaitis Paul D.
Northington-Davis Zinna
Williams Roger A.
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