LTA 4 hydrolase inhibitors

Details LTA 4 hydrolase inhibitors LTA 4 hydrolase inhibitors

2006-08-22

2006-08-22

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C558S169000, C562S016000

Reexamination Certificate

active

07094773

ABSTRACT:
The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A4(LTA4), and enzyme which is responsible for the biosynthesis of leukotriene LTB4, a major proinflammatory mediator. The invention also relates to therapeutic anti-inflammatory, applications of these compounds as well as for methods of preparing these compounds.

REFERENCES:
patent: 5508463 (1996-04-01), Smith, III et al.
patent: 5955461 (1999-09-01), Huth et al.
Lejczak et al “Synthesis of the Phosphonic Acid Analog of Serine” Synthesis, vol. 7, pp. 577-580 (1984).
Kukhar et al “Biological Activity of Phosphorus Analogs of Amino Acids” Ukr. Biokhim. Zh., vol. 60(6), pp. 95-111 (Nov.-Dec. 1988). (article in Russian).
Vasella and Voeffray “Asymmetric Synthesis of α-Aminophosphonic ACids by Cycloaddition of N-Glycosyl-C-dialkyloxyphosphonoylnitrones” Helvetica Chimica Acta, vol. 65(7), pp. 1953-1964 (1982).
Kukhar et al “Biological Activity of Phosphorus Analogs of Amino Acids” Ukr. Biokhim. Zh., vol. 60(6), pp. 95-111 (Nov.-Dec. 1988). (English Translation).
Ouazzani et al, “Synthesis of Enantionmerically Pure Phosphonic Analogues of Homoserine Derivatives” Tetrahedron: Asymmetry, vol. 2(9), pp. 913-917 (1991).
Shatzmiller et al, “Synthesis of α-Amino Phosphonic Acids via Oxoiminium Salts” Liebigs Annalen der Chemie, vol. 2, pp. 161-164 (1991).
Cheng and Goodwin, “Substrate-Related Phosphonopeptides, A New Class of Thrombin inhibitors” Tetrahedron Letters, vol. 32(49), pp. 7333-7336 (1991).
Finet et al, “Synthesis of 3-Amino-2-oxo-1,2-oxaphospholane and 3-Amino-2-oxo-1,2-oxaphosphorinane” Phosphorous, Sulfur and Silicon and the Related Elements, vol. 81(1-4), pp. 17-25 (1993).
Iversen et al, “Significance of Leukotriene-A4 Hydrolase in the Pathogenesis of Psoriasis” Skin Pharmacology, vol. 10, pp. 169-177 (1997).
Tsuji et al, “Effects of SA6541, a leukotrienes A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis” European Journal of Pharmacology, vol. 346, p. 81-85 (1998).
Tsuji et al, “Involvement of Leukotriene B4 in Arthritis Models” Life Sciences, vol. 64(3), pp. PL51-PL56 (1999).

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