Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
1999-02-26
2001-01-16
Shah, Mukund J. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S255010, C514S331000, C514S489000, C514S551000, C514S552000, C514S613000, C544S169000, C544S389000, C546S233000, C554S106000, C560S032000, C560S162000, C564S123000, C564S191000
Reexamination Certificate
active
06174885
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative and, in particular, to a [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative that has excellent hair growth effect.
BACKGROUND OF THE INVENTION
At the present time, scalp abnormality due to activation of androgen in an organ such as hair root or sebaceous gland, lowering of blood stream toward hair follicle, excess secretion of sebum, generation of peroxide and the like has been considered as a cause of baldness or hair loss. Accordingly, a compound or composition that can remove or reduce the above-mentioned problems has been generally included into a hair growth promoting composition to promote hair growth and regrowth and to prevent hair loss, for a long time (in the present invention, “hair growth promoting composition” includes hair regrowth promoting composition, and the like).
At present, compounds or crude drug extracts having various functions have been compounded to the hair growth promoting composition. These functions include blood flow promoting action, topical stimulation, hair follicle activating action, antiandrogen action, antiseborrheic action and the like have been known. Examples of drugs having blood flow promoting action include swertia herb extract, vitamin E and its derivative, and benzyl nicotinate. Examples of drugs which promote blood circulation by topical stimulation include capsicum tincture, cantharides tincture, camphor and vanillic acid nonylamide. Examples of drugs having hair follicle activating action include hinokitiol, placental extract, photosensitizing dye, pantothenic acid and derivative thereof. Examples of drugs having antiandrogen action include estradiol and estrone. Examples of drugs having antiseborrheic action include sulfur, thioxolone and vitamin B
6
.
In addition to these drugs, salicylic acid, resorcine and the like that have comeocyte desquamating action and antibacterial action can be compounded to hair growth promoting composition for the purpose of preventing dandruff. Further, glycyrrhizic acid, menthol and the like can be compounded in order to prevent inflammation of scalp. Furthermore, amino acids, vitamins, extracts of crude drugs and the like can be compounded so as to aliment to hair follicle and activate enzyme activity.
Meanwhile, for example, D (L)-pantolactone (Unexamined Japanese Patent Publication No. Hei 8-26942), 2(1H)-pyridone derivative (Unexamined Japanese Patent Publication No. Hei 8-20521), N
G
-nitro-L-arginine (Unexamined Japanese Patent Publication No. Hei 7-316023), 3-methyleneisoindolin-1-one derivative (Unexamined Japanese Patent Publication No. Hei 7-316022), indole derivative (Unexamined Japanese Patent Publication No. Hei 7-304736) are disclosed in recent patents as drugs having hair regrowth effect, hair growth effect, and hair loss protecting effect.
However, although the drugs described above are compounded to the conventional hair growth promoting compositions, they do not always exhibit sufficient hair regrowth and growth promoting effect.
SUMMARY OF THE INVENTION
In view of the foregoing problem in the prior art, an object of the present invention is to provide a compound, which is excellent in hair growth and regrowth promoting effect on human hair, and a hair growth promoting composition comprising the same as an active ingredient.
As a result of diligent studies of the inventors for attaining the above mentioned objects, it has been found that certain [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative and its salt have excellent hair growth and regrowth promoting effect, thereby accomplishing the present invention.
Namely, a [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof in accordance with the present invention is expressed by the following Formula (I):
wherein
each of A and B is R
1
or —(CH
2
)n-NR
2
R
3
, wherein when A is R
1
, B is —(CH
2
)n-NR
2
R
3
and when A is —(CH
2
)n-NR
2
R
3
, B is R
1
;
Z is —O—, —OCO—, —OCONR
6
— or —NR
6
—;
R
1
is a hydrocarbon group of C
10-30
;
R
2
and R
3
individually represent a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group, or together represent a heterocycle having 3-7 members;
when A is —(CH
2
)n-NR
2
R
3
, —NR
5
—A may be Group W, and when —Z—B is —OCONR
6
—(CH
2
)n-NR
2
R
3
or —NR
6
—(CH
2
)n-NR
2
R
3
, —Z—B may be a group of —OCO—W or Group W, wherein said Group W is expressed by the following Formula:
wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R
2
is a hydrogen atom, a lower alkyl group, a phenyl group or a benzyl group;
R
4
is selected from the group consisting of a halogen atom, a lower alkyl group, a lower acyl group, a nitro group, a cyano group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkylamino group, a lower acylamino group, a lower alkoxy group and a lower acyloxy group;
R
5
is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group, and when A is —(CH
2
)n-NR
2
R
3
, —NR
5
—A may be said Group W;
R
6
is a hydrogen atom, a lower alkyl group, a lower acyl group or a lower alkylcarbamoyl group, and when —Z—B is —OCONR
6
—(CH
2
)n-NR
2
R
3
or —NR
6
—(CH
2
)n-NR
2
R
3
, —Z—B may be —OCO—W or said Group W;
m is an integer of 0-2; and
n is an integer of 0-5.
A hair growth promoting composition in accordance with the present invention is characterized by comprising said [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the pharmacologically acceptable salt thereof as an effective ingredient.
An external preparation for skin in accordance with the present invention is characterized by comprising said [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the pharmacologically acceptable salt thereof.
A method for promoting hair growth in accordance with the present invention is characterized by applying an effective amount of said [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the pharmacologically acceptable salt thereof on the skin of mammals and, in particular, on human scalp.
REFERENCES:
patent: 4628061 (1986-12-01), Jones et al.
patent: 0 811 370 A1 (1997-12-01), None
patent: 7-304736 (1995-11-01), None
patent: 7-316022 (1995-12-01), None
patent: 7-316023 (1995-12-01), None
patent: 8-020521 (1996-01-01), None
patent: 8-026942 (1996-01-01), None
Fukunishi Hirotada
Kobayashi Koji
Magara Tsunao
Coleman Brenda
Shah Mukund J.
Shiseido Co. Ltd.
Snider Ronald R
Snider & Associates
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