LRF Antagonists

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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2601125LH, A61K 3700, C07C10352

Patent

active

043860745

ABSTRACT:
Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure:

REFERENCES:
patent: 4215038 (1980-07-01), Rivier et al.
"Peptides", Structure and Biological Function, Coy et al., Article, pp. 775-779.
Journal of Medicinal Chemistry, 1977, vol. 20, No. 4, pp. 495-500.
Int. J. Peptide Protein Res., vol. 10, 1977, Felix et al., pp. 299-310.
Chem. Abstr. 91, 1979, p. 33213d.
C. W. Beattie, J. of Med. Chem. 18, No. 12, 1975, 1247-1250.

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