Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1991-08-22
1994-01-25
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, A61K 3170, A61K 31715
Patent
active
052815838
ABSTRACT:
An analgesic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED.sub.50 is 0.4-100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0% in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100% is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, high cholesterol level of said animal is prevented or cured; and a method of treating pain of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the pain of said animal.
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patent: 4612304 (1986-09-01), Fukushi
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Seppala, et al., Chem. Abst. 102:44031q, 1985.
Jacobs, et al., Chem. Abst. 85:141214q, 1976.
Mizuno Den'ichi
Oshima Haruyuki
Soma Gen-Ichiro
Tsukioka Daisuke
Yoshimura Kiyoshi
Mizuno Den'Ichi
Rollins John W.
Soma Gen-Ichiro
Yamasaki Kazuyuki
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