LPAAT-β inhibitors and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S196000, C544S198000, C544S204000, C544S207000, C544S215000

Reexamination Certificate

active

07064125

ABSTRACT:
The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.

REFERENCES:
patent: 5702717 (1997-12-01), Cha et al.
patent: 6288288 (2001-09-01), Henkin et al.
patent: 2002/0065270 (2002-05-01), Moriarty et al.
patent: 2104232 (1971-09-01), None
patent: 2311237 (1974-09-01), None
patent: 2833582 (1979-02-01), None
patent: 084 767 (1983-08-01), None
patent: 096 189 (1983-12-01), None
patent: 01-261307 (1989-06-01), None
patent: 11-158073 (1999-06-01), None
patent: WO 91/11465 (1981-08-01), None
patent: WO 93/17002 (1993-09-01), None
patent: WO 96/04281 (1996-02-01), None
patent: WO 00/43369 (2000-07-01), None
patent: WO 01/47897 (2001-07-01), None
West et al. DNA Cell Biol. 16(6): 691-701, 1997.
Britten and Kohne, “Repeated Sequences in DNA,”Science 161(3841): 529-540, Aug. 9, 1968.
Bursten et al., “Interleukin-1 Rapidly Stimulates Lysophosphatidate Acyltransferase and Phosphatidate Phosphohydrolase Activities in Human Mesangial Cells,”Journal of Biological Chemistry 266(31): 20732-20743, Nov. 5, 1991.
Bursten et al., “Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phophatidic acid,”American Journal of Physiology 262(2): C328-C338, Feb. 1992.
Curd et al.,J. Chem. Soc. 160-162, 1947. Database Crossfire Beilstein, Database Accession No. 49402.
Cuthbertson et al.,J. Chem. Soc., 561-563, 1948. Database Crossfire Beilstein, Database Accession No. 35104, 284744.
Degussa, ZA 6707089, 1968. Chemical Abstracts 70:57905, 1969. And Database Crossfire Beilstein, Database Accession No. 1158601.
Eberhardt et al., “Human Lysophosphatidic Acid Acyltransferase,”Journal of Biological Chemistry 272(32): 20299-20305, Aug. 8, 1997.
English, D., “Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signaling,”Cell Signal 8(5): 341-347, 1996.
Fong and Engleman, “Dendritic Cells in Cancer Immunotherapy,”Annual Review of Immunology 18: 245-273, 2000.
Freiberg et al.,J. Prakt. Chem. 327(3): 471-478, 1985. Chemical Abstracts 104:68822.
Goi et al.,Yuki Gosei Kagaku Kyokaishi 18: 332-336, 1960. Database Crossfire Beilstein, Database Accession No. 895595.
Hoess and Abremski, “The Cre-lox Recombination System,”Nucleic Acids and Molecular Biology 4: 99-109, 1990.
Imamura et al, “Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D,”Biochemical and Biophysical Research Communications 193(2): 497-503, Jun. 15, 1993.
Kester, M., “Platelet-Activating Factor Stimulates Phosphatidic Acid Formation in Cultured Rat Mesangial Cells: Roles of Phospholipase D, Diglyceride Kinase, and De Novo Phospholipid Synthesis,”Journal of Cellular Physiology 156: 317-325, 1993.
Kim et al.,Journal of the Korean Chemical Society 42(1): 118-121, 1998. Chemical Abstracts 128:282822.
Kim et al.,Journal of the Korean Chemical Society 43(4): 497-499, 1999. Chemical Abstracts 131:286468.
Köhler and Milstein, “Continuous cultures of fused cells secreting antibody of predefined specificity,”Nature 256: 495-497, Aug. 7, 1975.
Kotova-kilot et al.,TR. Mosk Khim.-Tekhnol. Inst. 61: 157-159, 1970. Chemical Abstracts 73:98911.
Kume and Shimizu, “cDNA Cloning and Expression of Murine 1-Acyl-sn-glycerol-3-phosphate Acyltransferase,”Biochemical and Biophysical Research Communications 237(3): 663-666, Aug. 28, 1997.
Langalia et al.,J. Indian Chem. Soc. 59(9): 1099-1101, 1977. Chemical Abstracts 98:89321.
Laurent et al., Justus Liebigs Ann. Chem 60: 846, 1970. Database Crossfire Beilstein, Database Accession No. 33800.
Leung et al., “Molecular Cloning of Two Alternatively Spliced Forms of Human Phosphatidic Acid Phosphatase cDNAs that Are Differentially Expressed in Normal and Tumor Cells,”DNA and Cell Biology 17(4): 377-385, Apr. 1998.
Losman et al., “Baboon anti-idiotype antibodies mimic a carcinoembryonic antigen epitope,”Int. J. Cancer 46(2): 310-314, Aug. 15, 1990.
Martin et al., “Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts,”Oncogene 14(13): 1571-1580, Apr. 3, 1997.
Metha et al.,J. Inst. Chem(India) 59(4): 183-185, 1987. Chemical Abstracts 109:6485.
Miller and Rosman, “Improved Retroviral Vectors for Gene Transfer and Expression,”BioTechniques 7(9): 980-EOA, Oct. 1989.
Moolenaar, W.H., “Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger,”Journal of Biological Chemistry 270(22): 12949-12952, Jun. 2, 1995.
Neicheva et al.,Journal of Planar Chromatography-Modern TLC 12(2): 145-149, 1999. Chemical Abstracts 131:28881.
Orlandi et al., “Cloning immunoglobulin variable domains for expression by the polymerase chain reaction,”Proc. Natl. Acad. Sci. USA 86(10): 3833-3837, May 1989.
Rajnani et al.,J. Inst. Chem.(India) 49(4): 222-224, 1977. Chemical Abstracts 88:37757.
Rajnani et al.,J. Inst. Chem.(India) 48(5): 254-255, 1976. Chemical Abstracts 86:189869.
Rao et al.,J. Inst. Chem.(India) 54(5): 199-200, 1982.
Rizzo et al., “The Recruitment of Raf-1 to Membranes Is Mediated by Direct Interaction with Phosphatidic Acid and Is Independent of Association with Ras,”Journal of Biological Chemistry 275(31): 23911-23918, Aug. 4, 2000.
Sauer, B., “Inducible Gene Targeting in Mice Using the Cre/lox System,”Methods: A Companion to Methods in Enzymology 14(4): 381-392, Apr. 1998.
Schreurs et al., “Dendritic Cell-Based Vaccines: From Mouse Models to Clinical Cancer Immunotherapy,”Critical Reviews in Oncogenesis 11(1): 1-17, 2000.
Sharp et al., “Viral DNA in Transformed Cells. I. A Study of the Sequences of Adenovirus 2 DNA in a Line of Transformed Rat Cells Using Specific Fragments of the Viral Genome,”J. Mol. Biol. 86(4): 709-726, Jul. 15, 1974.
Stamps et al., “A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases,”Biochemical Journal 326:455-461, Sep. 1, 1997.
Sutton, W.D., “A crude nuclease preparation suitable for use in DNA reassociation experiments,”Biochimica et Biophysica Acta 240(4): 522-531, Jul. 29, 1971.
Unishi et al.,Nippon Kagaku Kaishi 1:40-44, 1987. Chemical Abstracts 107:134287.
Wakabayashi et al.,Nippon Dojo-Hiryogaku 41(5): 193-200, 1970. Chemical Abstracts 73:108869.
West et al., “Cloning and Expression of Two Human Lysophosphatidic Acid Acyltransferase cDNAs That Enhance Cytokine-Induced Signaling Responses in Cells,”DNA and Cell Biology 16(6): 691-701, Jun. 1997.
Wetmur and Davidson, “Kinetics of Renaturation of DNA,”Journal of Molecular Biology 31(3): 349-370, Feb. 14, 1968.
Xu et al, “Lysophospholipids activate ovarian and breast cancer cells,”Biochemical Journal 309: 933-940, Aug. 1, 1995.

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