Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2005-04-05
2005-04-05
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C558S170000
Reexamination Certificate
active
06875757
ABSTRACT:
The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
REFERENCES:
patent: 3639571 (1972-02-01), Turesky et al.
patent: 5480877 (1996-01-01), Mosher, Jr. et al.
patent: 5565439 (1996-10-01), Piazza et al.
patent: 5750141 (1998-05-01), Roberts et al.
patent: 5837845 (1998-11-01), Hosokawa et al.
patent: 5945522 (1999-08-01), Cohen et al.
patent: 0 394 663 (1990-10-01), None
patent: 0 425 680 (1991-05-01), None
patent: 861463 (1961-02-01), None
patent: WO 9809668 (1998-03-01), None
patent: WO 9841213 (1999-02-01), None
patent: WO 9908514 (1999-02-01), None
patent: WO 9947101 (1999-09-01), None
Noort et al., Bioorganic & Medicinal Chemistry Letters (Aug. 20, 1996), 6(16), pp. 2007-2012.*
Avaeva et al., CA 73:31861, 1970.*
Cherbuliez et al.,Helv. Chim. Acta,43:863-867 (1960), Beilstein Registry No. 1909896.
Cameron et al.,Phosphorus, Sulfur Silicon Relat. Elem.,83(1-4):21-38 (1993), Beilstein Registry No. 1759257.
Avaeva et al.,Moscow Univ. Chem. Bull.,26(5):87 (1971), Beilstein Registry No. 2124207.
Cherbuliez et al.,Helv. Chim. Acta,39:1455-1456 (1956), Beilstein Registry No. 1782157.
Vutz et al.,Liebigs Ann. Chem.,8:1259-1270 (1980), Beilstein Registry No. 4500093.
Burger et al.,J. Org. Chem.,20:1383-1385 (1955), Beilstein Registry No. 3711336.
Blickenstaff et al.,Steroids,46(4,5):889-902 (1985), Beilstein Registry No. 6258294.
Bigham et al., Heterocycles, 35(2):1289-1307 (1993) Beilstein Registry No. 6366843.
Valerio et al.,Aust. J. Chem.,45(4):777-784 (1992), Beilstein Registry No. 5338529.
Piantadosi et al.,J. Med. Chem.,34(4):1408-1414 (1991), Beilstein Registry No. 4331312.
Hosokawa et al., Chem. Pharm. Bull., 17:202-206 (1969), Beilstein Registry No. 6293905.
Helferich et al., Justus Liebigs Ann. Chem., 655:59-69 (1962), Beilstein Registry No. 2736669.
Chavane et al., Ann. Chim., 4:372-379 (1949), Beilstein Registry No. 1761550.
Snyder et al.,Biochemistry,11(9):1616-23 (1972) (abstract).
Geleji et al.,J. Polymer Sci.,58:955-75 (1962) (abstract).
Galardy,Biochemistry,21(3):5777-81 (1982) (abstract).
Kimizuka et al.,Chem. Lett.,1:29-30 (1999), Beilstein Registry No. 8250411.
Hamachi et al.,J. Amer. Chem. Soc.,119(39):9096-9102 (1997), Beilstein Registry No. 7849035.
Ichinose et al.,Chem. Lett.,4:257-258 (1996) Beilstein Registry No. 7608508.
Kunitake et al.,J. Chem. Soc. Perkin Trans.,2(6):885-890 (1991), Beilstein Registry No. 4776258.
Baker et al.,J. Pharm. Sci.,54:845-847 (1965), Beilstein Registry No. 1154148.
Jeck et al.,Justus Liebigs Ann. Chem.,531:533-34 (1973), Beilstein Registry No. 624232.
Scola-Negalschneider et al.,Eur. J. Biochem.,66:567, 570-574 (1976), Beilstein Registry No. 1053625.
Savarese et al.,Biochemical Pharmacology,40(11):2465-71 (1990) (abstract).
Streichter et al.,Chemica Scripta,26(1):179-83 (1986) (abstract).
Campbell,Biochim. Biophys. Acta,232:427 (1971), Beilstein Registry No. 1159691.
Holy,Collect. Czech. Chem. Commun.,40:187, 209 (1975), Beilstein Registry No. 3995566.
Jeck et al.,Justus Liebigs Ann. Chem.,961:962, 967 (1973), Beilstein Registry No. 4066019.
Cherbuliez et al.,Helv. Chim, Acta,50:979-985 (1967), Beilstein Registry No. 3100496.
Cherbuliez et al.,Helv. Chim. Acta,49:2608-2615 (1966), Beilstein Registry No. 2753057.
Guibe-Jampel et al.,Bull. Soc. Chim. FR.,1308, 1312 (1971), Beilstein Registry No. 2372181.
Gefflaut et al.,Biorg. Med. Chem.,4(12):2043-2054 (1996), Beilstein Registry No. 7635283.
Gruen et al.,Chem. Ber.,45:3373 (1912), Beilstein Registry No. 1811344.
Patterson et al.,J. Biol. Chem.,264(14):8004-11 (1989) (abstract).
Kharchenko et al., “Thermal Stability and Antiseize Properties of Somes Phosphorus-Containing Lubricating Oil Additives,” 1974:523954CAPLUS81:123954 (1974) (abstract).
Li et al., “Site-Specific Photomodification of DNA by Porphyrin-Oligonucleotide Conjugates Synthesized via Solid Phase H-Phosphonate Approach,” 1997:164802CAPLUS126:141410 (1997) (abstract).
Gibbs, “The Synthesis of Phosphoramidates from Silyphosphites and Azides,” 1977:453513CAPLUS87:53513 (1977) (abstract).
Blume et al., “The Influence of Charge on Bilayer Membranes Calorimetric Investigations of Phosphatidic Acid Bilayers,” 1980:53762CAPLUS92:53762 (1980) (abstract).
Wei et al., “Study on New Amphoteric Surfactants of Phosphates I. Syntheses and Properties,” 1998:750143CAPLUS130:126594 (1998) (abstract).
Badalassi et al., “A Versatile Periodate-Coupled Fluorogenic Assay for Hydrolytic Enzymes,” 2000:859470CAPLUS134:174618 (2000) (abstract).
Bushnev et al., “Synthesis of Rac-3-benzoyl-1-deoxyceramide-1-phosphonic Acid,” 1983:405425CAPLUS99:5425 (1983) (abstract).
Cates, “Phosphorus-nitrogen Compounds 12 Phosphamidase Studies 2 N-alkylphosphoramidic Acids,” 1971:471703CAPLUS75:71703 (1971) (abstract).
Gasco et al., “Timolol in Lipospheres,” 1992:221452CAPLUS116:221452 (1992) (abstract).
Avaeva et al., “Hydrolysis of Phosphoric Ester Serine Derivatives Containing Free Amino or Carboxylic Groups,” 1972:34548CAPLUS76:34548 (1972) (abstract).
Valerio et al., “Synthesis of the Simple Peptide Model Ac-Abu (PO3H2)-NHMe,” 1992:236128CAPLUS116:236128 (1992) (abstract).
Ryan et al., “Synthesis, Structure-Activity Relationships, and the Effect of Polyethylene Glycol on Inhibitors of Phosphatidylinositol-Specific Phospholipase C fromBacillus cereus,” 1996:618920CAPLUS126:16188 (1996) (abstract).
Swarthout et al., “Lysophosphatidic Acid: Receptors, Signaling and Survival,”CMLS, Cell. Mol. Life Sci.57:1978-1985 (2000).
Levine et al., “Lysophosphatidic Acid: A Novel Growth and Survival Factor for Renal Proximal Tubular Cells,” The American Physiological Society, pp 575-585 (1997).
Steiner et al., “Lysophosphatidic Acid Induction of Neuronal Apoptosis and Necrosis,”Annals New York Academy of Sciencespp 132-141, year not available.
Ediger et al., “Dual Effects of Lysophosphatidic Acid on Human Airway Smooth Muscle Cell Proliferation and Survival,”Biochimica et Biophysica Acta59-67 (2001).
Fang et al., “Lysophosphatidic Acid Prevents Apoptosis in Fibroblasts Via G1-Protein-Mediated Activation of Mitogen-Activated Protein Kinase,”Biochem J.352:135-143 (2000).
Frankel et al., “Peptide and Lipid Growth Factors Decrease cis-Diamminedichloroplatinum-Induced Cell Death in Human Ovarian Cancer Cells,”Clinical Cancer Research2:1307-1313 (1996).
Furui et al., “Overexpression of Edg-2/vzg-1 Induces Apoptosis and Anoikis in Ovarian Cancer Cells in a Lysophosphatidic Acid-Independent Manner,”Clinical Cancer Research5:4308-4318 (1999).
Goetzl et al., “Distinctive Expression and Functions of the Type 4 Endothelial Differentiation Gene-Encoded G Protein-Coupled Receptor for Lysophosphatidic Acid in Ovarian Cancer,”Cancer Research59:5370-5375 (1999).
Goetzl et al., “Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association With Suppression of Bax,” The American Association of Immunologists pp 2049-2056 (1999).
Koh et al., “Lysophosphatidic Acid Is a Major Serum Noncytokine Survival Factor for Murine Macrophages Which Acts Via The Phosphatidylinositol 3-Kinase Signaling Pathway,”J. Clin. Invest.716-727 (1998).
Holtsberg et al., “Lysophosphatidic Acid and Apoptosis of Nerve Growth Factor-Differentiated PC12 Cells,”Journal of Neuroscience Research53:685-696 (1998).
Holtsberg et al., “Lysophosphatidic Acid Induces Necrosis and Apoptosis in Hippocampal Neurons,”Journal of Neurochemistry66-76 (1998).
Baker Daniel L.
Dalton James T.
Elrod Don B.
Fischer David J.
Liliom Karoly
Stockton Laura L.
University of Tennessee Research Foundation
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