Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-08-02
1991-11-12
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514367, 514444, A61K 3138, A61K 3150, A61K 31425, A61K 31495
Patent
active
050648306
ABSTRACT:
Certain derivatives of oxophthalazinyl acetic acids of the formula ##STR1## wherein R.sub.1 is hydroxy or a prodrug group, and R.sub.2 and R.sub.3 are independently hydrogen, fluoro, chloro or trifluoromethyl, except that R.sub.2 and R.sub.3 are not both hydrogen, or a pharmaceutically acceptable base addition salt of a compound of formula I wherein R.sub.1 is hydroxy, are capable of lowering blood uric acid levels in mammals. These oxophthalazinyl acetic acid derivatives are for instance useful for treating gout and gouty arthritis in a mammal .
REFERENCES:
patent: 4939140 (1990-07-01), Larson et al.
Cited to Show State of the Art.
Friedman Stanley J.
Ginsburg Paul H.
Holtrust Gezina
Pfizer Inc.
Richardson Peter C.
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