Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation a

Details Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation a Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation a

1980-03-17

1981-04-28

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546258, C07D21322, A61K 31455

Patent

active

042646120

ABSTRACT:
Cardiotonic composition and method for increasing cardiac contractility using an effective amount of a cardiotonic lower-alkyl 2-halo-5-PY-6-Q'-nicotinate or pharmaceutically-acceptable acid-addition salt thereof, where halo is chloro or bromo, Q' is hydrogen or lower-alkyl and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. Also shown are novel lower-alkyl 2-halo-5-PY-6-(lower-alkyl)nicotinates or pharmaceutically-acceptable acid-addition salt thereof, useful as intermediates or cardiotonics and preparation thereof.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.
Balicki, et al., C.A., 87, (1977), 39357t.
Nantka-Namirski, et al., Pol. J. Pharmacol. Pharm., (1978), vol. 30, pp. 707-712.
Balicki, et al., Acta Poloniae Pharmaceutica, vol. 33, (1976), pp. 289-293.

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