Low viscosity solvent mixture for dissolution of cholesterol gal

Details Low viscosity solvent mixture for dissolution of cholesterol gal Low viscosity solvent mixture for dissolution of cholesterol gal

1988-02-19

1990-03-20

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514722, A61K 3123, A61K 3108

Patent

active

049102230

ABSTRACT:
A composition is described for the dissolution of cholesterol gallstones, which composition is a mixture of monooctanoin and diethyl ether and has a viscosity of not more than 7 cp and can be maintained in the body at a temperature below its boiling point. The volumetric ratio of monooctanoin:diethyl ether will usually be in the range of about 10:90 to about 70:30. The composition can be infused by a variety of techniques including high flow low pressure pumps.

REFERENCES:
patent: 4205086 (1980-05-01), Babayan
Allen et al. (I), Gastroenterology, 89, 5, 1097 (Nov., 1985).
Allen et al. (II), Gastroenterology, 88, 1, 122 (Jan., 1985).
Bogardus, J. Pharm. Sci., 73, 7, 906 (Jul., 1984).
Palmer et al., Gut, 27, 2, 196 (Feb., 1986).
Thistle et al., Gastroenterology, 78, 5, 1016 (May, 1980).

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