Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1986-01-06
1992-03-03
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536124, 536127, C07H 504
Patent
active
050934872
ABSTRACT:
The present disclosure is concerned with procedures for adjusting the average molecular weight, the molecular weight distribution and the viscosity in solution of hyaluronic acid and its salts (HA), particularly its sodium and potassium salts. The average molecular weight can be increased and the molecular weight distribution can be narrowed by precipitating this material into a bath of a non-solvent containing a continuously moving device to which it can adhere as it precipitates. The solution viscosity of this or any high molecular weight, high viscosity HA can be reduced without substantially effecting its molecular weight by either a moderate temperature heat treatment or passage through a fine (one micron or less) pore filter as a one weight percent or stronger aqueous solution. The disclosure is also concerned with the high molecular weight low solution viscosity HA so obtained.
REFERENCES:
patent: 2975104 (1961-03-01), Warren
patent: 3396081 (1968-08-01), Billck
patent: 4141973 (1979-02-01), Balazs
patent: 4517295 (1985-05-01), Bracke
Clark et al., "Experimental Biochemistry", 1977, Freeman and Co., pp. 230-231.
Fujiwa et al., Chemical Abstracts, vol. 105, 1986, No. 227738y.
Laurent et al., Chemical Abstracts, vol. 98, 1983, No. 211815f.
A. Mitra, S. Raghunathan, J. Sheehan and Struther Arnott, 1983, pp. 829-859, "Hyaluronic Acid: Molecular Conformations and Interactions in the Orthorhombic and Tetragonal Forms Containing Sinuous Chains".
Brown Karen K.
Bryant Sharon A.
Greene Nathan D.
Trump Sandy L.
Brown Johnnie R.
Gil Joseph C.
Mobay Corporation
Peselev Elli
Whalen Lyndanne M.
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