Low toxicity radiation sensitizer

Details Low toxicity radiation sensitizer Low toxicity radiation sensitizer

1982-11-12

1984-12-25

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424245, C07F 1500

Patent

active

044905432

ABSTRACT:
Bis(5-aminofluorescein)dichloroplatinum(II), and substituted fluoresceinamine derivatives of this compound are disclosed as highly effective radiation sensitizers which enhance the effect of ionizing radiation on tumor cells, but uniquely do so without the usual accompanying high toxicity level to surrounding normal cells. A direct combination, single step reaction synthesis is disclosed for preparing bis(5-aminofluorescein)dichloroplatinum(II) from the reaction between an alkali metal tetrachloroplatinate(II) and 5-aminofluorescein.

REFERENCES:
Chemical Abstracts, vol.94, (1981), 40620z.
J. Overgaard et al., Cancer Treatment Reports, (May/Jun. 1981), vol. 65, No. 5-6, pp. 501-503.

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