Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1976-01-05
1977-09-13
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424 3, 424322, A01N 102, A61K 3121, G01N 130
Patent
active
040483258
ABSTRACT:
A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.
REFERENCES:
raper, Ann, Soc. belge medtrop., vol. 49, 1969, pp. 205-210.
Lubin, Proc. Nat. Acad. Sci., USA, 72(1), pp. 43-46, Jan., 1975.
Dutton, Biochem. & Biophys. Res. Comm., vol. 23, No. 5, 1966, pp. 730-739.
Hunter, JACS, vol. 84, 1962, pp. 3491-3504.
Wheeler, Biochem & Biophys. Res. Commun., vol. 54, 1973, pp. 1024-1029.
Bymun Edwin N.
Packer Lester
Carlson Dean E.
Croft Irene S.
Fagelson A. P.
Gaither R. S.
Meyers Albert T.
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