Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Reexamination Certificate
2006-06-20
2010-02-16
Saoud, Christine J (Department: 1647)
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
C530S351000, C530S402000
Reexamination Certificate
active
07662370
ABSTRACT:
Interferon-alpha (IFNα) analog proteins modified by chemical attachment of at least one hydrophilic polymer moiety, such as polyethylene glycol chain, are described. In one embodiment, the IFNα analog protein has an amino acid sequence that differs from a native human IFNα interferon-alpha by one or more amino acid residues in the N-terminal region, comprised of between about residues 1-27, inclusive, by one or more substitutions selected based on the amino acid residue at the corresponding position of a mature interferon-tau (IFNτ) protein. Methods of treating viral diseases and other disorders with the polymer-modified IFNα analog protein are also described.
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Liu Chih-Ping
Villarete Lorelie H.
King & Spalding LLP
Mohr Judy M.
Pepgen Corporation
Saoud Christine J
Stoica Elly-Gerald
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