Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Wearing apparel – fabric – or cloth
Patent
1995-04-28
1997-04-01
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Wearing apparel, fabric, or cloth
264 41, 264 43, 264 46, 4284022, 436164, 514 78, A01N 2532, A01N 5726, A61K 31685
Patent
active
056163347
ABSTRACT:
Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
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Boni Lawrence
Cullis Pieter R.
Durning Anthony G.
Janoff Andrew S.
Kearns John J.
Lovering Richard D.
Rubin Kenneth B.
The Liposome Company Inc.
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