Low temperature process for preparing neomorphic ibuprofen

Details Low temperature process for preparing neomorphic ibuprofen Low temperature process for preparing neomorphic ibuprofen

1993-07-02

1994-05-10

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07L 53134

Patent

active

053109600

ABSTRACT:
A novel neomorphic form of ibuprofen and processes for its preparation are provided. The neomorphic ibuprofen is characterized by having a distinctively less bitter and acidic taste commonly associated with conventional ibuprofen and which causes less burning sensation upon swallowing. The neomorphic form of ibuprofen is an amorphous ibuprofen and is prepared by resolidifying supercooled ibuprofen at a process temperature below 0.degree. C.

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Vinod Labhasetwart, et al., Studies on Some Crystalline Forms of Ibuprofen, Drug Development and Industrial Pharmacy, 19(6), 631-641 (1993).

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