Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1981-07-24
1983-01-18
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
106210, 106213, 424361, 426578, A61K 4700, C13L 100, C08B 3100
Patent
active
043693083
ABSTRACT:
Starches useful as tablet disintegrants consist essentially of a free-flowing, crosslinked and pregelatinized starch powder having a moisture content of about 12% by weight or less. The starch is characterized by its uniformly swollen, virtually non-birefringent granules, by a swelling value in cold water of above 3 ml. and below 25 ml., and by an acid viscosity breakdown of 400 B.U. or less, all of which are correlated to this disintegration performance. The better starch disintegrants (i.e. the more highly crosslinked) have swelling values of 18 ml. or less and show little or no breakdown (0-150 B.U.). The modified starches may be used in any tabletting method (e.g. direct compression or granulation), typically in amounts of about 10% by weight or less.
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Griffin Ronald W.
Kelley Margaret B.
National Starch and Chemical Corporation
Szala Edwin M.
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