Low sodium peritoneal dialysis solution

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Elemental chlorine or elemental chlorine releasing inorganic...

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424678, 424680, 424681, 424682, 424686, 424717, 514 23, 514 54, 514557, A61K 3170, A61K 31715, A61K 3300, A61K 3314

Patent

active

055891977

ABSTRACT:
A peritoneal dialysis solution and method of administering same to a patient are provided wherein the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile (more volume over a longer period of time) for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities. A reduced amount of osmotic agent can be used to achieve equivalent ultrafiltration.

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Nakayama, Studies on the Sodium Concentration of Dialysate Solution for Continuous Ambulatory Peritoneal Dialysis, Japanese Journal of Nephrology, 34(8):913-20 (Aug. 1992).
Nakayama, Clinical Effect of Low Na Concentration Dialysate (120 mEq/L) for CAPD Patients, PD Conference, San Diego, CA (Mar. 1993).

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