Liquid purification or separation – Processes – Chromatography
Patent
1995-09-01
1997-10-28
Drodge, Joseph W.
Liquid purification or separation
Processes
Chromatography
210 91, 210144, 2101982, 210635, B01D 1508
Patent
active
056814747
ABSTRACT:
This invention relates to a low-pressure chromatography column 1 having a diameter of more than 30 cm, and essentially consisting of a vertical cylinder 13 having a base plate 12, a lower sintered disk 3 arranged above the base plate 12, an upper sintered disk 16 fastened to the underside of a lid designed as a mobile plunger 4, and having at least three controllable elements 5 for raising or lowering the plunger 4, which are connected to the plunger 4, equipped with sensors 6 electrically connected to a control unit 10 for determining the vertical position and horizontal placement of the plunger 4. With the aid of an optical observation device (e.g., endoscope), the plunger/gel material can be adjusted exactly over the entire positioning range of the plunger. The advantages of the invention include simple and rapid production of the packing and purer products than could be obtained without such packing. The low-pressure chromatography column according to the invention is particularly suitable for purifying insulin and precursors of insulin thereof.
REFERENCES:
patent: 3966609 (1976-06-01), Godbille et al.
patent: 4891133 (1990-01-01), Colvin
patent: 5324426 (1994-06-01), Joseph et al.
patent: 5450743 (1995-09-01), Buote
patent: 5462659 (1995-10-01), Saxena et al.
Gunther Joachim
Itter Klaus
Krause Bernhard
Mader Gernot
Simon Klaus-Jurgen
Drodge Joseph W.
Hoechst Aktiengesellschaft
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