Low pH pharmaceutical formulation containing t-PA

Details Low pH pharmaceutical formulation containing t-PA Low pH pharmaceutical formulation containing t-PA

1986-05-13

1990-05-29

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, A61K 37547

Patent

active

049294440

ABSTRACT:
A lyophilized pharmaceutical formulation of tissue plasminogen activator and a process for its preparation by vaccum drying a frozen aqueous solution of thereof, in which the pH is from 2 to 5.

REFERENCES:
patent: 3998947 (1976-12-01), D'Hinterland et al.
patent: 4505893 (1985-03-01), Mori et al.
patent: 4568544 (1986-02-01), Hasegawa et al.
patent: 4766075 (1988-08-01), Goeddel et al.
Dano et al, Biochimica et Biophysica Acta, 613 (1980) 542-555.
Remington's Pharmaceutical Sciences, Fifteenth Edition (1975), pp. 273-274.
Camiolo et al, cited in Biol. Abstracts 76(2)883 Ref. No. 8252 (1982).
Rote Liste, 1985.
J. Biol. Chem., 254(6) pp. 1998-2003, 1979, Binder, et al.
J. Biol. Chem., 256(13), 7035-7041, 1981.
Hamaguchi, Mie Medical Journal, vol. XXXIII, No. 1, 1983, pp. 57 and 66 to 67, Partial Purification and Properties of Tissue-Type Plaminogen Activator from Nasal and Maxillary Mucosae.
Collen, et al., Biological Properties of Human Tissue-Type Plasminogen Activator Obtained by Expression of Recombinant DNA in Mammalian Cells, The Journal of Pharmacology and Experimental Therapeutics, pp. 146-152, vol. 231, 1984.
Hoylaerts, et al., Kinetics of the Activation of Plasminogen by Human Tissue Plasminogen Activator, pp. 2912-2919, Journal of Biological Chemistry, vol. 257, No. 6, Mar. 25, 1982.

Affiliated with

Also associated with

Rating

Low pH pharmaceutical formulation containing t-PA does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Low pH pharmaceutical formulation containing t-PA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Low pH pharmaceutical formulation containing t-PA will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-519811