Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1987-12-10
1991-04-02
Moskowitz, Margaret
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
530351, C07K 1526
Patent
active
050046055
ABSTRACT:
Stable pharmaceutical compositions suitable for parenteral administration to mammals are prepared which are in a pH range of about 2 to about 4 and comprise a therapeutically effective amount of a recombinant interferon-.beta. protein (IFN-.beta.) dissolved in an inert carrier medium comprising as a stabilizer/solubilizer an effective amount either of glycerol or of polyethylene glycol polymers having an average molecular weight from about 190 to about 1600 daltons. Further disclosed and claimed are methods for extracting IFN-.beta. from a microbial host transformed to produce it and then purifying and formulating said IFN-.beta. and methods for screening for other polyhydric non-detergent stabilizer/solubilizers or combinations thereof as solubilizer/stabilizers for pharmaceutical compositions of IFN-.beta..
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Hershenson Susan
Thomson Jody
Cetus Corporation
Furman Keith C.
Halluin Albert P.
Lauder Leona
McGarrigle, Jr. Philip L.
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