Low molecular weight pulmonary surfactant proteins

Details Low molecular weight pulmonary surfactant proteins Low molecular weight pulmonary surfactant proteins

1990-04-09

1991-10-08

Nutter, Nathan M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530329, 536 22, 435 85, 4352401, A61K 3702, C07H 1900, C12P 1928, C12N 500

Patent

active

050555537

ABSTRACT:
This invention relates to novel proteins useful for enhancing pulmonary surfactant activity, methods and materials for obtaining said proteins and compositions containing one or more of the proteins.

REFERENCES:
patent: 4659805 (1987-04-01), Schilling, Jr. et al.
patent: 4882422 (1989-11-01), Taeusch et al.
Weinberg et al., "Isolation and Characterization of Human Apolipoprotein A-IV from Lipoprotein-Deleted Serum", J. Lipid Res., vol. 24, 1983, pp. 52-59.
Utermann et al., "Apolipoprotein A-IV: A Protein Occuring in Human Mesenteric Lymph Chylomicrons and Free in Plasma", Eur. J. Biochem. 99, 333-343 (1979).
Weisgraber et al., "Isolation and Characterization of an Apoprotein from the d>1.006 Lipoproteins of Human and Canine Lymph Homologous with the Rat A-IV Apoprotein", Biochem Biophys Res. Comm., vol. 85, No. 1, 1978, pp. 287-292.
Green et al., "Human Apolipoprotein A-IV-Intestinal Origin and Distriburion in Plasma", J. Clin. Invest., vol. 65, Apr. 1980, 911-919.
Beisiegel et al., "An Apolipoprotein Homolog of Rat Apolipoprotein A-IV in Human Plasma", Eur. J. Biochem. 93--601-608 (1979).
Floros et al., "Biosynthesis and in Vitro Translation of the Major Surfactant-Associated Protein from Human Lung", J. of Biol. Chem., vol. 260, No. 1, 495-500, Jan. 10, 1985.
Hawgood et al., "Effects of a Surfactant-Associated Protein and Calcium Ion on the Structure and Surface Activity of Lung Surfactant Lipids", Biochemistry, 1984, 24, 184-190.
Bhattacharyya et al., "Isolation and Characterization of Two-Hydroxyproline-Containing Glycoproteins from Normal Animal Lung Lavage and Lamellar Bodies", J. Clin. Invest., vol. 55, May 1975, 914-920.

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