Low-molecular weight peptides inhibiting ion channel activity

Details Low-molecular weight peptides inhibiting ion channel activity Low-molecular weight peptides inhibiting ion channel activity

2004-03-25

2008-07-08

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600

Reexamination Certificate

active

07396816

ABSTRACT:
It is intended to provide novel polypeptides which specifically inhibit the activity of a mechano-sensitive channel; and mechano-sensitive channel inhibitors or remedies for atrial fibrillation containing these polypeptides or salts thereof. The above objects can be achieved by using polypeptides having amino acid sequences represented by SEQ ID NO:1 (TVP003), SEQ ID NO:2 (TVP004) and SEQ ID NO:3 (TVP005), salts of these polypeptides, and mechano-sensitive channel inhibitors or remedies for atrial fibrillation containing the same.

REFERENCES:
patent: WO 01/76618 (2001-10-01), None
Bowie Ju et al., Deciphering the message in protein sequences:tolerance to amino acid substitutions, Mar. 1990, Science, v247 pp. 1306-1310.
Robert E. Oswald et al., “Solution Structure of Peptide Toxins That Block Mechanosensitive Ion Channels”, Journal of Biological Chemistry, Sep. 13, 2002, pp. 34443-34450, vol. 27, No. 37, American Society of Biological Chemical Biologists, Birmingham, U.S.A.
Kimberly Laskie Ostrow et al., “cDNA sequence and in vitro folding of GsMT=4, a specific peptide inhibitor of mechanosensitive channels”, TOXICON, vol. 42, No. 3, Sep. 3, 2003, pp. 263-274.
Philip A. Gottlieb et al., “Mechanosensitive Ion Channels as Drug Targets”,Current Drug Targets. CNS & Neurological Disorders, 2004, pp. 287-295, vol. 3, No. 4, Bentham Science Publishers, Hilversum, Netherlands.
European Search Report dated Apr. 19, 2006, issued in correspondong European Patent Application No. EP 04723309.3.
T. M. Suchyna et al.; “Identification of a Peptide Toxin fromGrammostola spatulataSpider Venom that Blocks Cation-selective Stretch-activated Channels”, The Journal of General Physiology, vol. 115, No. 5, 2000, pp. 583-598. Cited in ISR.
Frank Bode et al.; “Tarantula peptide inhibits atrial fibrillation”, Nature, vol. 409, No. 6816, 2001, pp. 35-36. Cited in ISR.
Owen White et al.; “Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1”, Science, vol. 286, 1999, pp. 1571-1577. Cited in ISR.
S. R. H. Russell et al.; “Dropophila melanogasterMale Germ Line-Specific Transcripts With Autosomal and Y-Linked Genes”, Genetics, vol. 134, 1993, pp. 293-308. Cited in ISR.

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