Low molecular weight carbohydrates as additives to stabilize met

Details Low molecular weight carbohydrates as additives to stabilize met Low molecular weight carbohydrates as additives to stabilize met

1992-03-30

1993-09-28

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424617, 424646, 436173, 1286534, 514 23, 514 53, 514814, G01N 2408, A61K 3324, A61K 3326, A61K 3170

Patent

active

052484920

ABSTRACT:
This invention relates to compositions comprising a colloidal or particulate metal oxide which are stabilized by low molecular weight carbohydrates. The carbohydrates are characterized by the fact that a) they are not retained on the surface of the metal oxide based on the equilibrium room temperature dialysis of about 2 ml of the metal oxide composition at 0.2M metal concentration against deionized water; and b) they impart sufficient stability to the metal oxide compositions such that the compositions can withstand heat stress without perceptible aggregation as determined by a prescribed test procedure.

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