Surgery: kinesitherapy – Kinesitherapy – Ultrasonic
Reexamination Certificate
2011-03-01
2011-03-01
Chen, Tse (Department: 3777)
Surgery: kinesitherapy
Kinesitherapy
Ultrasonic
Reexamination Certificate
active
07896821
ABSTRACT:
A method and device selectively and reversibly disrupts the blood-brain barrier (BBB) in a selected volume of the brain without the need for exogenous agents. The method and device employ low intensity directed ultrasound (LODUS) that is safe, reduces the danger of cavitation and thermal tissue damage, and is able to expose small or large regions of the brain to achieve a desired therapeutic or prophylactic effect.
REFERENCES:
patent: 5752515 (1998-05-01), Jolesz et al.
patent: 6514221 (2003-02-01), Hynynen et al.
patent: 2003/0009153 (2003-01-01), Brisken et al.
Akiyama et al., Abstract of “Low-frequency Ultrasound Penetrates the Cranium and Enhances Thrombolysis In Vitro,” Neurosurgery 43:828-833 (1998).
Alexandrov, “High Rate of Recanalization and Dramatic Clinical Recovery During tPA infusion When Continuously Monitored With 2-MHz Transcranial Doppler Monitoring,” Stroke 31:610-614 (1998).
Bao et al., “Transfection of a Reporter Plasmid Into Cultured Cells by Sonoporation,” Ultrasound in Med. & Biol. 23:953-959 (1997).
Behrens et al., “Low-Frequency, Low-Intensity Ultrasound Accelerates Thrombolysis Through the Skull,” Ultrasound in Med. & Biol. 25(2):269-273 (1999).
Black et al., “Modulation of Brain Tumor Capillaries for Enhanced Drug Delivery Selectively to Brain Tumor,” Maxine Dunitz Neurosurgical Institute and Burns and Allen Research Institute, Cancer Control, 11(3):165-173 (2004).
Carstensen et al., “The Search for Cavitation In Vivo,” Ultrasound in Med. & Biol. 26(9): 1377-1385 (2004).
Church C., “Spontaneous Homogenous Nucleation, Inertial Cavitation in vivo,” Ultrasound in Med. & Biol. 28(10):1349-1364 (2002).
Fellner et al., “Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo” J. Clin. Invest. 110(9):1309-18 (2002).
Francis et al., “Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots,” Ultrasound in Med. & Biol. 21(3): 419-24 (1995).
Goodman and Gilman,The Pharmacological Basis of Therapeutics,7th Ed., Macmillan Publishing Co., New York, pp. 5-13 (1985).
Groothuis, “The blood-brain and blood-tumor barriers: A review of strategies for increasing drug delivery,” Neuro-Oncology 2:45-59 (2000).
Guzman H.R., Abstract of “Ultrasound Mediated Disruption of Cell Membranes, Quantification of molecular uptake and cell viability,” Acoustic Soc. Am. 2001 10(1) 588-596 (2001).
Hiesiger et al., Abstract of “Opening the Blood-Brain and Blood-Tumor Barriers in Experimental Rat Brain Tumors: The Effect and Intracarotid Hyperosmolar Mannitol on Capillary Permeability and Blood Flow,” Annals of Neurology, 19:50-59 (1986).
Huber, Abstract of “Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery,” Gene Therapy, 10:1800-1807 (2003).
Huber et al., “Molecular physiology and Pathophysiology of tight junctions in the blood-brain barrier,” Trends Neuroscience 24(12): 719-725 (2001).
Hynynen, “Trans-skull Ultrasound Therapy: The Feasibility of Using Image-Derived Skull Thickness Information to Correct the Phase Distortion,” IEEE Transactions UFFC 46(3):752-755 (1999).
Hynynen et al., “MRI Guided Focal Blood Brain Barrier Opening Using focused Ultrasound” Ultrasonics Symposium p. 1417 (2000).
Hynynen et al.,“Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits” Radiology 220(3): 640-646 (2001).
Hynynen et al., “The Threshold for Brain Damage in Rabbits induced by Bursts of Ultrasound in the Presence of an Ultrasound Contrast Agent (Optison®),” Ultrasound in Med. & Biol. 29(3):473-481 (2003).
Hynynen et al., “Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications,” NeuroImage 24:12-20 (2005).
Karshafian et al., “How do Ultrasound & Microbubbles Influence Drug Uptake?” U. Toronto, Conference Poster.
Kim et al., “Ultrasound-Mediated Transfection of Mammalian Cells,” Human Gene Therapy 7: 1339-1346 (1996).
Kroll et al., Abstract of “Improving drug delivery to intracerebral tumor and surrounding brain in a rodent model: a comparison of osmotic versus bradykinin modification of the blood-brain and/or blood-tumor barriers,” Neurosurgery 43(4):879-86 (1998).
Kudo S., “Thrombolysis with Ultrasound Effect,” Tokyo Jikeikai Medical J. 104:1005-1012 (1989).
Li et al., “Gene Transfer with Echo-enhanced Contrast Agents,” Radiology (2003).
Luo et al., “Transcutaneous ultrasound augments lysis of arterial thrombi in vivo” 94(4):775-778 (1996).
Maruvada et al., “Optical Monitoring of Ultrasound-Induced BioEffects in Glass Catfish,” Ultrasound in Med. & Biol. 30(1): 67-74 (2004).
Mesiwala et al., “High-Intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo,” Ultrasound in Med. & Biol. 28(3): 389-400 (2002).
Miller et al., “Sonoporation of monolayer cells by diagnostic ultrasound activation of contrast-agent gas bodies,” Ultrasound in Med. & Biol. 26: 661-667 (2000).
Molnar et al., Abstract of “The blood-brain barrier in primary CNS lymphomas: Ultrastructural evidence of endothelial cell death” Neuro-oncology 1(2):89-100 (1999).
Muldoon et al., “Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delievery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain,” Am. J. Path. 147(6): 1840-1851 (1995).
Nag S., “Morphology and Molecular Properties of Cellular Components of Normal Cerebral Vessels,”The Blood-Brain Barrier: Biology and Research Protocols,p. 3-36 (2003).
E.A. Neuwelt, Abstract of “Mechanisms of disease: the blood brain barrier,” Neurosurgery 54(1):131-40 (2004).
Neuwelt et al., Abstract of “Cerebrovascular permeability and delivery of gentamicin to normal brain and experimental brain abscess in rats,” Journal of Neurosurgery 61:430-439 (1984).
Neuwelt and Dahlborg, “Blood-Brain barrier disruption in the treatment of brain tumors: Clinical Implications,”Implications of the blood-brain barrier and its Manipulation,p. 195-261 (1989).
W. M. Pardridge, Abstract of “Drug and Gene Targeting to the Brain with Molecular Trojan Horses,” Nature Reviews Drug Discovery 1:131-139 (2002).
Patrick et al., Abstract of “Ultrasound and the Blood-Brain Barrier,” Adv. Exp. Med. Biol. 267:369-381 (1990).
Prados et al., Abstract of “A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma,” Neuro-oncology 5(2): 96-103 (2003).
Poliachik et al., “Activation, Aggregation and Adhesion of Platelets Exposed to High-Intensity Focused Ultrasound,” Ultrasound in Med. & Biol. 27(11):1567-1576 (2001).
Remsen et al., Abstract of “The Influence of anesthetic choice, PaCO2, and other factors on osmotic blood-brain barrier disruption in rats with brain tumor xenografts,” Anesth. Analg. 88(3): 559-567 (1999).
Riggs et al., Abstract of “Ultrasound enhancement of rabbit femoral artery thrombolysis,” Cardiovasc. Surg. 5(2):201-207 (1997).
Sheikov et al., “Cellular Mechanisms of the Blood-Brain Barrier Opening Induced by Ultrasound in Presence of Microbubbles,” Ultrasound in Med. & Biol. 30(7):979-989 (2004).
Suchkova et al., “Effect of 40-kHz ultrasound on acute thrombotic ischemia in a rabbit femoral artery thrombosis model: enhancement of rabbit and improvement in capillary muscle perfusion,” Circulation 101(19): 2296-2301 (2000).
Suchkova et al., “Ultrasound
Herken Ulrich
Kyle Albert S.
Magnin Paul A.
Cesari and McKenna LLP
Chao Elmer
Chen Tse
O'Donnell Martin J.
Perfusion Technology, LLC
LandOfFree
Low intensity directed ultrasound (LODUS) mediated blood... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Low intensity directed ultrasound (LODUS) mediated blood..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Low intensity directed ultrasound (LODUS) mediated blood... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2687198