Low foaming, aqueously homogenizable rifampin composition

Details Low foaming, aqueously homogenizable rifampin composition Low foaming, aqueously homogenizable rifampin composition

1987-04-06

1989-06-06

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424464, 424 78, 514255, A61K 948, A61K 3174

Patent

active

048370290

ABSTRACT:
An antibiotic composition comprising rifampin, a dimethyl polysiloxane polymer, and a cationic or non-ionic surfactant, wherein the rifampin, dimethyl polysiloxane polymer, and surfactant are present in relative amounts such that the composition is aqueously homogenizable with low foaming.
Also disclosed is a method of antibiotic treatment wherein such composition is administered orally, either in a solid dosage form or in an aqueous medium.

REFERENCES:
patent: 4195084 (1980-03-01), Ong
patent: 4332789 (1982-06-01), Mlodozeniec
patent: 4613496 (1986-09-01), Kopf
patent: 4687662 (1987-08-01), Schobel

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