Low flux matrix system for delivering potent drugs transdermally

Details Low flux matrix system for delivering potent drugs transdermally Low flux matrix system for delivering potent drugs transdermally

1993-08-09

1996-09-10

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 424487, 602 54, A61L 1524

Patent

active

055543812

ABSTRACT:
Matrix-type transdermal drug delivery devices for administering potent steroids such as ethinyl estradiol at a low flux steady-state rate over a multi-day period comprising a laminate of: (a) an occlusive backing layer and (b) a matrix layer of the drug completely dissolved at a loading of below 0.5% by weight in a 2-ethylhexyl acrylate copolymer.

REFERENCES:
patent: 4906169 (1990-03-01), Chien et al.
patent: 4994267 (1991-02-01), Sablotski
patent: 5145682 (1992-09-01), Chien et al.
patent: 5252334 (1993-10-01), Chiang et al.
patent: 5300291 (1994-04-01), Sablotsky et al.
patent: 5393529 (1995-02-01), Hoffmann et al.

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