Low estrogen oral contraceptives

Details Low estrogen oral contraceptives Low estrogen oral contraceptives

1991-12-12

1993-11-16

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514170, 514179, 514843, A61K 3156

Patent

active

052624080

ABSTRACT:
Disclosed is a contraceptive regimen, and method of using the regimen, comprising 24 daily sequential dosage units of: a first phase comprising about 7 to 9 separate first dosage units containing a progestogen at a daily dosage equivalent in progestogenic activity to 100 desogestrel and an estrogen at a daily dosage equivalent in estrogenic activity to 25 .mu.g ethinyl estradiol ("EE"). A second phase of 7 to 9 second dosage units, each of the second dosage units containing a progestogen equivalent to 125 .mu.g desogestrel and an estrogen equivalent lent to 20 .mu.g EE. A third phase of 7 to 9 third dosage units, each unit containing a progestogen equivalent to 50 .mu.g desogestrel and an estrogen equivalent to 20 .mu.g EE. The kit generally has 28 daily dosage units wherein four of the daily dosage units contain no contraceptive steroid, or, alternatively, have only 24 dosage units with a four day "pill-free" period. The fourth phase may also be four dosage units containing a progestogen equivalent to 25-35 .mu.g desogestrel.

REFERENCES:
patent: 4378356 (1983-03-01), de Jager et al.
patent: 4544554 (1985-10-01), Pasquale
patent: 4616006 (1986-10-01), Pasquale
patent: 4628051 (1986-12-01), Pasquale
CA 114:88652v, De Jager, 1990.

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