Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Combination of antigens from multiple viral species
Patent
1994-08-12
1996-10-15
Caputa, Anthony C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Combination of antigens from multiple viral species
424 936, 4242291, 424816, 4352351, 435237, 435239, A61K 39255, A61K 3912
Patent
active
055652026
ABSTRACT:
A vaccine for Marek's disease using mutant strains of a serotype 2 field isolate, designated 471B/1, is disclosed. The mutant viruses, which are produced by serial passage of 471B/1 in cell culture, not only retain effective immunizing ability against Marek's disease virus, but which also exhibit reduced enhancement of lymphoid leukosis in comparison to non-passaged 471B/1 and conventional serotype 2 vaccines. These viruses or immunogenic components thereof can be formulated into monovalent and polyvalent vaccines.
REFERENCES:
patent: 4895717 (1990-01-01), Witter
patent: 4895718 (1990-01-01), Witter
patent: 5378467 (1995-01-01), Bexendale
Witter, et al. "Biological Diversity Among Serotype 2 Marek's disease Viruses", Avian Diseases 34:944-957 1990.
Witter, R. L. "Association in broiler chickens between Natural serotype 2 Marek's disease virus infection and leukosis condemnations". In:Proc. International Symposium or Marek's Disease-B. W. Calnek and J. C. Spencer, ed. American Association of Avian Pathologists, Kennett Square, PA pp. 545-554 1985.
Witter, Richard L., Abstract of oral Presentation, "Serotype 2 Marek's Disease Vaccines With Reduced Ability to Enhance Lymphoid Leukosis", World Veterinary Poultry Association, Australia, 16-19 Aug. 1993.
Caputa Anthony C.
Deck Randall E.
Fado John D.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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