Low dose pharmaceutical powders for inhalations

Details Low dose pharmaceutical powders for inhalations Low dose pharmaceutical powders for inhalations

2011-06-07

2011-06-07

Alstrum Acevedo, James H (Department: 1616)

Surgery

Respiratory method or device

Means for mixing treating agent with respiratory gas

C424S046000, C424S489000

Reexamination Certificate

active

07954491

ABSTRACT:
The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of a patient. The invention also relates to receptacles containing the particle mass and the inhaler for use therein.

REFERENCES:
patent: 3795244 (1974-03-01), Lax et al.
patent: 4069819 (1978-01-01), Valentini et al.
patent: 4884565 (1989-12-01), Cocozza
patent: 4995385 (1991-02-01), Valentini et al.
patent: 5192528 (1993-03-01), Radhakrishnan et al.
patent: 5669378 (1997-09-01), Pera et al.
patent: 5819726 (1998-10-01), Rubsamen et al.
patent: 5833647 (1998-11-01), Edwards et al.
patent: 5855913 (1999-01-01), Hanes et al.
patent: 5874064 (1999-02-01), Edwards et al.
patent: 5921236 (1999-07-01), Ohki et al.
patent: 5985309 (1999-11-01), Edwards et al.
patent: 5985320 (1999-11-01), Edwards et al.
patent: 6012450 (2000-01-01), Rubsamen
patent: 6060069 (2000-05-01), Hill et al.
patent: 6116239 (2000-09-01), Volgyest
patent: 6136295 (2000-10-01), Edwards et al.
patent: RE37053 (2001-02-01), Hanes et al.
patent: 6254854 (2001-07-01), Edwards et al.
patent: 6284282 (2001-09-01), Maa et al.
patent: 6387390 (2002-05-01), Deaver et al.
patent: 6399102 (2002-06-01), Edwards et al.
patent: 6406681 (2002-06-01), Adjei et al.
patent: 6436443 (2002-08-01), Edwards et al.
patent: 6447752 (2002-09-01), Edwards et al.
patent: 6447753 (2002-09-01), Edwards et al.
patent: 6503480 (2003-01-01), Edwards et al.
patent: 6565885 (2003-05-01), Tarara et al.
patent: 6635283 (2003-10-01), Edwards et al.
patent: 6652837 (2003-11-01), Edwards et al.
patent: 6652873 (2003-11-01), Deaver et al.
patent: 6705313 (2004-03-01), Niccolai
patent: 6732732 (2004-05-01), Edwards et al.
patent: 6740310 (2004-05-01), Edwards et al.
patent: 6766799 (2004-07-01), Edwards et al.
patent: 7146978 (2006-12-01), Edwards et al.
patent: 7278425 (2007-10-01), Edwards et al.
patent: 2001/0004892 (2001-06-01), Datta et al.
patent: 2001/0027790 (2001-10-01), Gieschen et al.
patent: 2002/0046751 (2002-04-01), MacRae et al.
patent: 2002/0177562 (2002-11-01), Weickert et al.
patent: 2003/0085480 (2003-05-01), Yang
patent: 2004/0025876 (2004-02-01), Miller et al.
patent: 2005/0074498 (2005-04-01), Tarara et al.
patent: WO 94/14492 (1994-07-01), None
patent: WO 02/083220 (2002-10-01), None
Cipolla et al. “Bolus Administration of INS365: Studying the Feasibility of Delivering High Dose Drugs Using the AERx® Pulmonary Delivery System,” Respiratory Drug Delivery VII, (May 14-16) 2000, pp. 231-239.
Lacy, C.; Armstrong, L. L.; Lipsy, R. J.; Lance, L. L. Drug Information Handbook, Lexi-Comp, Inc.: Cleveland, 1993, pp. 30-31 and 94-96.
Olsson et al. “Critical Aspects of the Function of Inspiratory Flow Driven Inhalers,” Journal of Aerosol Medicine, 1994, 7 (supplemental 1), pp. S43-S47.
de Boer et al. “Inhalation Characteristics and Their Effects on in vitro Drug Delivery from Dry Powder Inhalers Part 1. Inhalation Characteristics, Work of Breathing and Volunteers' Preference in Dependence of the Inhaler Resistance,” International Journal of Pharmaceutics 1996, 130, pp. 231-244.
Dal Negro et al., “Peak Inspiratory Flow Rate, as Measured Through a New Powder Inhaler . . . ,” Advances in Therapy, Jul./Aug. 1997, 14(4), pp. 181-190.
Ruggins, et al., “An Assessment of a New Breath Actuated Inhaler Device in Acutely Wheezy Children,” Archives of Disease in Childhood, 1993, 68(4), pp. 477-480.
Wildhaber et al., “Lung Deposition of Budesonide from TURBUHALER in Asthmatic Children,” Eur. J. Pediatr. 1998, 157, 1017-1022.
Pellegrino, R. et al. “On the Causes of Lung Hyperinflation During Bronchoconstriction,” Eur. Respir. J. 1997, 10, pp. 468-475.
Thorsson, L. et al. “Lung Deposition of Budesonide From TURBUHALER® is Twice that From a Pressurized Metered-Dose Inhaler P-MDI,” Eur. Respir. J. 1994, 7, pp. 1839-1844.
Melchor, R. Thorax, 1993, 48, pp. 506-511.
Sebti, T. et al. “Pharmacoscintigraphic Evaluation of Lipid Dry Powder Budesonide Formulations for Inhalation,” European Journal of Pharmaceutics and Biopharmaceutics, 2006, 64, pp. 26-32.
Newman, S. P. et al. “Scintigraphic Comparison of Budesonide Deposition From Two Dry Powder Inhalers,” Eur. Respir. J. 2000, 16, pp. 178-183.
U.S. Appl. No. 09/591,307 (Allowed), filed Jun. 9, 2000, Edwards, et al.
Dunbar, et al., “In vitro and in vivo dose delivery characteristics of large porous particles for inhalation,”Int. J. Pharm., 245:179-189 (2002).
Annals of the ICRP Publication 66, Human Respiratory Tract Model for Radiological Protection, Sections (1-3), Elsevier Science, New York (1994).

Affiliated with

Also associated with

Rating

Low dose pharmaceutical powders for inhalations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Low dose pharmaceutical powders for inhalations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Low dose pharmaceutical powders for inhalations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2689183