Low dose oral contraceptives with less breakthrough bleeding and

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514170, 514182, 514843, A61K 3156

Patent

active

055523943

ABSTRACT:
A method of female contraception which is characterized by a reduced incidence of breakthrough bleeding after the first cycle involves monophasicly administering a combination of estrogen and progestin for 23-25 consecutive days of a 28 day cycle in which the daily amounts of estrogen and progestin are equivalent to about 5-35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively and in which the weight ratio of estrogen to progestin is at least 1:45 calculated as ethinyl estradiol to norethindrone acetate.

REFERENCES:
patent: 3932635 (1976-01-01), Segre
patent: 5010070 (1991-04-01), Boissonneault
patent: 5098714 (1992-03-01), Wright
patent: 5262408 (1993-11-01), Bergink
CA 76:30782, Craft et al., 1971.
Martindale, The Extra Pharmacopoeia, Edited by James E. F. Reynolds, pp. 2003-2004, Thirtieth Edition. (1993).
AHFS Drug Information 33, p. 2348. (1993).
Drug Information for the Health Care Professional, vol. 1, USP DI 1993, 13th Edition, Chapter 50.

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