Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1992-04-28
1999-06-08
Fitzgerald, David L.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 854, 424 855, 424 856, A61K 3821
Patent
active
059103043
ABSTRACT:
Improved methods for administering an interferon (IFN) to a warm-blooded vertebrate are described. The methods employ oral administration of the IFN to the vertebrate in very low dosages, for example, 0.1 to 1.5 IU per pound of body eight per dose.
REFERENCES:
patent: 3536809 (1970-10-01), Applezweig
patent: 3906092 (1975-09-01), Hillerman et al.
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 4053582 (1977-10-01), Stickl
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4250163 (1981-02-01), Nagai et al.
patent: 4273703 (1981-06-01), Osther et al.
patent: 4276282 (1981-06-01), Sugimoto et al.
patent: 4460574 (1984-07-01), Yabrov
patent: 4462985 (1984-07-01), Cummins, Jr.
patent: 4497795 (1985-02-01), Cummins
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4605555 (1986-08-01), Sato et al.
patent: 4649075 (1987-03-01), Jost
patent: 4675184 (1987-06-01), Hasegawa et al.
patent: 4699136 (1987-10-01), Krauser
patent: 4710191 (1987-12-01), Kwiatek et al.
patent: 4713239 (1987-12-01), Babaian et al.
patent: 4746508 (1988-05-01), Carey et al.
patent: 4764378 (1988-08-01), Keith et al.
patent: 4803072 (1989-02-01), Dalton et al.
patent: 4820515 (1989-04-01), Cummins
patent: 4828830 (1989-05-01), Wong
patent: 5830456 (1998-11-01), Cummins
Toneva, V., Bulletin de l'Office International des Epizooties, vol. 88, 1977, pp. 631-637 (Summary).
Rodder, H., Thuman, D., Thuman, E., Tierarztliche Umschau, vol. 34, No. 10, 1979, pp. 720-724 (Summary).
"In Vivo and Clinical Studies," Norman B. Finter & Robert K. Oldham, eds., Interferon, vol. 4, 1985, pp. 137, 148, 173, 218, 226, 284, 285, 330. on the Antibody Formation in Chicks with Pseudopest," Litvinov, A.N.
"Time and Dosage Dependence of Immunoenhancement by Murine Type II Interferon Preparations", Sonnenfeld et al., Cellular Immunology, 40, 1978, pp. 285-293.
"Interferons and Their Actions", W.E. Stewart II and A.A. Gotlieb, eds., 1977, pp. 102-104.
"Antiviral Effect of Bacterially Produced Human Interferon (Hu-IFNa.sub.2) Against Experimental Vaccinia Infection in Calves", Journal of Interferon Research, 5:129-126, 1985, Werenne, J. et al.
"Effect of Human Leukocyte A Interferon on Prevention of Infectious Bovine Rhinotracheitis Virus Infection of Cattle", Roney, C.S. et al., Am. J. Vet. Res., vol. 46, No. 6, Jun. 1985, pp. 1251-1255.
"Response of Feline Leukemia Virus-Induced Nonregenerative Anemia to Oral Administration of an Interferon-Containing Preparation", Feline Practice, vol. 12, No. 3, No. 3, May-Jun. 1982, pp. 6-15, Tompkins, M.B. and Cummins, J.
"Interferon Enters The Fray", Farm Journal, Oct. 1985, pp. 12-13, Miller, B.
"Interferon as an Adjuvant for Hepatitis B Vaccination in Non- and Low-Responder Populations", Grob, P.J. et al., Eur. J. Clin. Microbiol., Jun. 1984, vol. 3, No. 3, pp. 195-198.
"Protection of Calves Against Rhinovirus Infection by Nasal Secretion Interferon Induced by Infectious Bovine Rhinotracheitis Virus", American Journal of Veterinary Research, Cummins, J.M. and Rosenquist, B.D., Feb., 1980, vol. 41, No. 2, pp. 161-165.
"Bovine Respiratory Disease--A Symposium", R.W. Loan, ed., Texas A&M University Press, College Station, TX, 1984 pp. 484-485.
"Activity of Exogenous Interferon In The Human Nasal Mucosa", Texas Reports on Biology and Medicine, vol. 35, 1977, Greenberg, S.B., et al., pp. 491-496.
"Inhibition of Respiratory Virus Infection by Locally Applied Interferon", Merigan, T.C., et al., The Lancet, Mar. 17, 1973, pp. 563-567.
"Trials of Interferon in Respiratory Infections of Man", Tyrrell, D.A.J., Texas Reports on Biology and Medicine, vol. 35, 1977, pp. 486-490.
"Bacteria-Derived Human Leukocyte Interferons After in Vitro Humoral and Cellular Immune Responses", Shalaby, M.R. and Weck, P.K., Cellular Immunology, 82, 1983, pp. 269-281.
"Clinical and Laboratory Investigations on Man: Systemic Administration of Potent Interferon to Man", Strander, H., et al., J. Natl. Cancer Inst., 51: 733-742, 1973.
"Application of Human Leukocyte Interferon in Severe Cases of Virus B Hepatitis", Vlatkovic, R., et al., Proc. Symposium on Interferon 1979, Yugoslav Academy of Sciences and Arts, Zagreb, pp. 173-183.
"Effect of Interferon on Vaccination in Volunteers", The Lancet, Apr. 28, 1962, pp. 873-875 (Report to Medical Research Council from the Scientific Committee on Interferon).
"Induction of Ocular Resistance to Vaccinia Virus by Typhoid Vaccine: Role of Interferon", Oh, J.O. and Yoneda, C., The Journal of Immunology, vol. 102, No. 1, 1969, pp. 145-154.
"Clinical Trials With Exogenous Interferon: Summary of a Meeting", The Journal of Infectious Diseases, vol. 139, No. 1, Jan. 1979, pp. 109-123.
"Some Results and Prospects in the Study of Endogenous and Exogenous Interferon", The Interferons, An International Symposium, Soloviev, V.D., Geo. Rita, ed., Academic Press, 1968, pp. 233-243.
"Influenza and Interferon Research in the Soviet Union--Jan. 1973", The Journal of Infectious Diseases, vol. 128, No. 2, Aug. 1973, pp. 261-264.
"The Results of Controlled Observations on the Prophylaxis of Influenza with Interferon", Solov'ev, V.D., World Health Organization, 1949, 41, 683-688.
"Children's Respiratory Viral Diseases Treated With Interferon Aerosol", Jia-xiong, D., et al., Chinese Medical Journal, 100(2): 162-166, 1987.
Essential Clinical Virology, R.G. Sommerville, Blackwell Scientific Publications, pp. 154-157.
"Comparative Intranasal Pharmacokinetics of Interferon Using Two Spray Systems", Davies, H.W. et al., J. Interferon Research, 1983, pp. 443-449.
"The Common Cold: Control?", Couch, R.B., The Journal of Infectious Diseases, vol. 150, No. 2, Aug. 1984, pp. 167-173.
Principles and Practice of Infectious Diseases, 2nd ed., Mandell, G.L., Douglas, R.G. Jr., Bennett, J.E., eds., A. Wiley Medical publication, pp. 85-96, 863, 968.
Antiviral Agents and Viral Diseases of Man, edited by G.J. Galasso, T.C. Merigan, R.A. Buchanan, Raven Press, New York, 1979, pp. 407-408, 430-431.
Antiviral Agents and Viral Diseases of Man, 2nd ed., edited by G.J. Galasso, T.C. Merigan, R.A. Buchanan, Raven Press, New York, 1979, pp. 407-408, 430-431.
"Interferon Perspective", Information on Interferon provided in 1981 by the International Preventative Medicine Foundation, Melbourne FL, Ronald Jones, Vice President.
American Interhealth, Melbourne Beach, Florida, Production Information.
Biovet International, Inc., Canine and Feline Interferons, 1981 Product Description and Label.
"Agriferon.RTM.-C", Immuno Modulators Laboratories, Inc., Stafford, Texas, Lymphokine Preparation for prophylactic treatment of infectious bovine rhinotracheitis virus associated with shipping fever--for cattle use in Texas only, product brochure.
"Agriferon.RTM.-C" A bold new approach to managing shipping fever in cattle. Immuno Modulators Laboratories, Inc., Stafford, Texas, product advertisement.
"Equiferon" A totally new approach to viral respiratory infection in horses, Immuno Modulators Laboratories, Inc., Stafford, Texas, product advertisement.
"Pet Interferon Alpha", Amarillo Cell Culture Company, Inc., Amarillo, Texas, Lymphokine Preparation for treatment of feline leukemia virus and canine parvovirus diseases, product brochure.
Texas Department of Health Application for License, Amarillo Cell Culture Company, Inc., for Human Interferon Alpha, (Alpha Interferon) as Pet Interferon, May 6, 1985.
"Circulating Interferon in Rabbits After Administration of Human Interferon by Different Routes", Cantel, K. and Ryhala, L., Journal of General Virology, 1973, 20, pp. 97-104.
"Pharmacokinetics of Recombinant Alpha A Interferon Following IV Infusion and Bolus, IM, and PO Administrations to African Green Monkeys", Wills, R.J., et al., Journal of Interferon Research, vol. 4, No. 3, 1984, pp. 399-409.
"Pharmacokinetics of Recombinant Leukocyte A Interferon Following Various Routes and Modes of Administration to the Dog", Gibson, D.M., et al., Journal of Interferon Research, 5:403-408 (1985).
"Stimulation of Humoral Immunity by Interferon", III Mediterranean Congress of Chemotherapy, Smerdel, S., et al., Sep. 21-24, 1982 presentation, vol. 2, p. 132, Oct.
Fitzgerald David L.
Texas A&M University System
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