Low dosage treatment for cocaine craving and withdrawal

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514252, 514327, 514382, 514396, 514812, A61K 3150, A61K 3156, A61K 31495

Patent

active

058694749

ABSTRACT:
Ketoconazole is used for treating cocaine addiction. Mammals, including humans, that are chronically addicted to cocaine are treated with ketoconazole to decrease self-administration of the drug.

REFERENCES:
patent: 4661493 (1987-04-01), Gibbs
patent: 4814333 (1989-03-01), Ravaris
patent: 4942162 (1990-07-01), Rosenburg et al.
patent: 5456850 (1995-10-01), Liu et al.
Goeders et al., "Effects of Ketoconazole on Intravenous Cocaine Self-Administration in Rats," an abstract submitted to the Fifty-Eighth Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD), Jun. 22-27, 1996.
H.D. Kleber, "Pharmacotherapy, Current and Potential, for the Treatment of Cocaine Dependence," Clinical Neuropharmacology, vol. 18, Suppl. 1, pp. S96-S109 (1995).
Di Paolo et al., "Endocrine and Neurochemical Actions of Cocaine," Canadian Journal of Physiology and Pharmacology, vol. 67, pp. 1177-1181 (1989).
Joels et al., "Mineralocorticoid and Glucocorticoid Receptors in the Brain. Implications for Ion Permeability and Transmitter Systems," Progress in Neurobiology, vol. 43, pp. 1-36 (1994).
Baumann et al., "Effects of Intravenous Cocaine on Plasma Cortisol and Prolactin in Human Cocaine Abusers," Biological Psychiatry, vol. 38, pp. 751-755 (1995).
Mendelson et al., "Buprenorphine Attenuates the Effects of Cocaine on Adrenocorticotropin (ACTH) Secretion and Mood States in Man," Neuropsychopharmacology, vol. 7, No. 2,, pp. 157-162 (1992).
Heesch et al., "Effects of Cocaine on Cortisol Secretion in Humans," American Journal of the Medical Sciences, vol. 310, No. 2, pp. 61-64 (1995).
Gawin et al., "Cocaine Dependence," Annual Review of Medicine, vol. 40, pp. 149-161 (1989).
Goeders et al., "Non-contingent Electric Footshock Facilitates the Acquisition of Intravenous Cocaine Self-Administration in Rats," Psychopharmacology, vol. 114, pp. 63-70 (1994).
Goeders et al., "Role of Corticosterone in Intravenous Cocaine Self-Administration in Rats," Neuroendocrinology vol. 64, pp. 337-348 (1996).
Goeders et al., "Effects of Surgical and Pharmacological Adrenalectomy on the Initiation and Maintenance of Intravenous Cocaine Self-Administration in Rats," Brain Research, vol. 722, pp. 145-152 (1996). Inhibition of.
Piazza et al., "Inhibition of Corticosterone Synthesis by Metyrapone Decreases Cocaine-Induced Locomotion and Relapse of Cocaine Self-Administration," Brain Research, vol. 658, pp. 259-264 (1994).
N. Sonino, "The Use of Ketoconazole as an Inhibitor of Steroid Production," New England Journal of Medicine, vol. 317 (No. 13), pp. 812-818 (1987).
Engelhardt et al., "Ketoconazole Blocks Cortisol Secretion in Man by Inhibition of Adrenal 11.beta.-Hydrolase," Klin. Wochenschr., vol. 63, pp. 607-612 (1985).
Ghadirian et al., The Psychotropic Effects of Inhibitors of Steroid Biosynthesis in Depressed Patients Refractory to Treatment, Biological Psychiatry, vol. 37, pp. 369-375 (1995).
Wolkowitz et al., "Ketoconazole Administration in Hypercortisolemic Depression," American Journal of Psychiatry, vol. 150, pp. 810-812 (1993).
Goeders et al., "Ketoconazole Reduces Intravenous Cocaine Self-Administration in Rats," submitted for publication in Psychopharmacology (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Low dosage treatment for cocaine craving and withdrawal does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Low dosage treatment for cocaine craving and withdrawal, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Low dosage treatment for cocaine craving and withdrawal will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1948550

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.