Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1996-04-15
1997-08-26
Rollins, John W.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
424 944, 514886, C12N 996, A61K 3844
Patent
active
056610203
ABSTRACT:
Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation.
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Abuchowski, A., Doctor of Philosophy Thesis, "Effects of convalent Attachment of Polyethylene Glycol on Bovine Serum Albumin and Bovin Liver Catalase", Rutgers University, New Brunswick, NJ. USA Oct. 1975.
Veronese, F. M., et al., J. of Pharm. & Pharmacol., 35:757-758 1983.
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Kazo, G. M., Master of Science in Biochemistry Thesis, "Modification of Proteins with Activated polyethylene Glycols", Rutgers University, New Brunswick, NJ Oct. 1985.
Hoyer Denton W.
Ladd David L.
Snow Robert A.
Balogh Imre
Davis William J.
DuPont Paul E.
Rollins John W.
Sanofi
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