Low density lipoprotein fraction assay for cardiac disease risk

Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus

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204469, G01N 2726, G01N 27447

Patent

active

059252294

ABSTRACT:
A variable rate density gradient electrophoric gel is described which separate LDL subfractions with the precision of ultracentrifugation techniques. Also, an innovative bottom inlet mixing chamber particularly useful for producing these gels is described.

REFERENCES:
patent: 5387325 (1995-02-01), Opplt
patent: 5589104 (1996-12-01), Bambeck
David L. Rainwater et al "Production of polyacrylamide gradient gels for the electrophoretic resolution of lipoproteins " Journal of Lipid Reasearch, vol. 33, pp. 1876-1881, No month available, 1992.
Rainwater, Audres, Ford, Lowe, Blanche & Krauss "Production of Polyacryamide Gradient Gels for electrophoretic resolution of Lipoproteins"J. Lipid Research vol. 33, p. 1876, No month available,1992.
Singh, Rainwater et al "Effect of Diabetes on Lipoprotein Size" Arteriosclerosis, Thrombosis, and Vascular Biology vol. 15, p. 1805, No month available, 1995.
Krauss & Blanche "Detection and quantitation of LDL subfractions" Current Opinion in Lipidology vol. 3, p. 377, No month available, 1992.
Krauss "Low Density Lipoprotein Subclasses and Risk of Coronary Artery Disease" COL, vol. 2, p. 248, No month available, 1991.
Nichols, Krauss & Musliner, "Nondenaturing Polyacrylamide Gradient Electrophoresis" Methods in Enzymology vol. 128, p. 417, No month available, 1986.
Krauss & Burke "Identification of Multiple subclasses of Plasma Low Density Lipoproteins in Normal Humans" J. of Lipid Research, vol. 23, p. 97, No month available, 1982.
Williams, Vranizan & Krauss "Correlations of Plasma Lipoproteins with LDL Subfractions by Particel Size in Men and Women" No month available J of Lipid Research vol. 33, p. 765, 1992.

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