Low crystallinity cellulose excipients

Details Low crystallinity cellulose excipients Low crystallinity cellulose excipients

1995-04-25

1997-10-07

Gardner, Sallie M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424488, 424499, 424464, 81271, 536 56, 514951, 514960, A61K 700, A61K 914

Patent

active

056745079

ABSTRACT:
A rapid method to prepare low crystallinity cellulose (crystallinity 15-45% of polymerization 35-150), suitable for use as a direct compression excipient (e.g., binder, disintegrant, and diluent) in pharmaceutical solid dosage forms design and as a bodying and/or film forming agent in the development of sustained- and/or film forming agent in the development of sustained- and/or controlled-release pharmaceutical (topical and transdermal products), cosmetics, agricultural, personal care and like products, is provided by reacting cellulose materials with 85% or higher weight percentage phosphoric acid under controlled sequenced temperature conditions that involve treatment first at room temperature for an hour and then at 50.degree.-55.degree. C. for 3-6 hours, followed by separating by a precipitation method,. and subsequently isolating as a powder or converting into a head or hydrated form.

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patent: 4575376 (1986-03-01), Shah
patent: 4919681 (1990-04-01), Tyler
patent: 5244734 (1993-09-01), Okuma

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