Low crystallinity cellulose excipients

Details Low crystallinity cellulose excipients Low crystallinity cellulose excipients

1992-12-14

1995-05-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424499, 424464, 424401, 81271, 536 56, 514951, 514960, A61K 914, A61K 920

Patent

active

054179840

ABSTRACT:
A rapid method to prepare low crystallinity cellulose (crystallinity 15-45% of polymerization 35-150), suitable for use as a direct compression excipient (e.g., binder, disintegrant, and diluent) in pharmaceutical solid dosage forms design and as a bodying and/or film forming agent in the development of sustained- and/or film forming agent in the development of sustained- and/or controlled-release pharmaceutical (topical and transdermal products), cosmetics, agricultural, personal care and like products, is provided by reacting cellulose materials with 85% or higher weight percentage phosphoric acid under controlled sequenced temperature conditions that involve treatment first at room temperature for an hour and then at 50.degree.-55.degree. C./ for 3-6 hours, followed by separating by a precipitation method,. and subsequently isolating as a powder or converting into a head or hydrated form.

REFERENCES:
patent: 2978446 (1961-04-01), Battista et al.
patent: 3146170 (1964-08-01), Battista
patent: 4058411 (1977-11-01), Bellamy
patent: 4357467 (1982-11-01), Sachetto
patent: 4575376 (1986-03-01), Shah
patent: 4919681 (1990-04-01), Tyler
patent: 5244734 (1993-09-01), Okuma

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