Low affinity human IL-12 beta2 receptor

Details Low affinity human IL-12 beta2 receptor Low affinity human IL-12 beta2 receptor

1997-08-19

1999-07-06

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 930120, 514 2, 514 8, C07K 14705

Patent

active

059199032

ABSTRACT:
A recombinant human IL-12 receptor complex produced on the surface of a non-human mammalian cell and free from other human proteins, the complex comprising the beta1 receptor protein complexed with a beta2 receptor protein, which complex is capable of binding to human IL-12 with high affinity. A recombinant human IL-12 beta2 receptor protein produced on the surface of a non-human mammalian cell, free from other human proteins, in its active form. In addition, a non-human mammalian cell having expressed on its surface the recombinant human IL-12 beta2 receptor protein or the recombinant human IL-12 receptor complex, which cell proliferates in the presence of human IL-12. A non-human mammalian cell having the human IL-12 beta2 receptor protein or the complex expressed on its surface and which proliferates in response to human IL-12 is useful for determining whether a given compound inhibits biological activity of human IL-12 or is an IL-12 agonist.

REFERENCES:
patent: 5536657 (1996-07-01), Chua et al.
S. Grant. et al. 1990, Proc. Natl. Acad. Sci. USA 87:4645.
Gately, et al., J. Natl. Cancer Inst. 69 1245 (1982).
P. Chomczynski & N. Sacchi, Anal. Biochem. 162:156, 1987.
K. Kuribayashi et al. Nucl. Acids Res. Symposium Series 19:61, 1988.
U. Gubler & A. Chua, Essential Molecular Biology vol. II, T.A. Brown, editor pp. 39-56 TRL Press 1991.
A. Aruffo & B. Seed, Proc. Natl. Acad. Sci (USA) 94, 8573, 1987.
Hara & Miyajima 1992, EMBO 11:1875.
Grunstein & Hogness, Molecular Cloning Proc. Nat. Acad. Sci. USA 72:3961 (1975).
McPherson J., 1985, Pharmacol Methods, 14:213.
Palacios R., et al., 1985, Cell 41:727.
Giordano, T.J. et al. 1990, Gene 88:285.
vonHeijne G., 1986, Nucl. Acids Research 14:4683.
Presky, D., et al., Res. Immunol. 146 439-445 (1995).
Ellison et al., Nucl. Acid Res. 10 4071-4079.
Huck, et al., Nucl. Acid Res 14 1779-1789 (1986).
Presky, et al., PNAS 93(24), pp. 14002-14007 (1996).
Gubler, et al., FASEB J. 10(6), A1326 (1996).
Szabo et al., FASEB J. 10(6), A1310 (1996).
Gately, M.K. et al., 1991, J. Immunol. 147:874.
Kobayashi, M., et al., 1989, J. Exp. Med. 170:827.
Stern, A.S. et al., 1990, Proc. Natl. Acad Sci. USA 87:6808.
Gately, M.K., 1992, Cell Immunology 143:127.
Chan, S.H. et al., 1991, J. Exp. Med. 173:869.
Manetti, R., et al., 1993, J. Exp. Med. 177:1199.
Hsieh, C.S. et al., 1993, Science 260:547.
Chizzonite, R., et al., 1992, J. Immunol. 148:3117.
Desai, B., et al., J. Immunol, 1992, 148:3125.
Desai, B., et al., 1993, J. Immunol. 150:207A.
Chizzonite, R., et al., 1994, Cytokine 6(5):A82a.
Chua, A., et al., 1994, J. Immunology 153:128.
Stahl & Yancopoulos, 1993, Cell 74:587.
Charnow, S.M., et al., Trends in Biotechnology vol.14 52-60 (1996).
M.O. Dayhoff, et al., Methods Enzymology 91:524 (1983).
U. Gubler, et al., 1991, Proc. Natl. Acad. Sci USA 88:4143.
H.W. Lahm et al. 1985, J. Chromatog. 326:357.
S. Mizushima & S. Nagata, Nucl. Acids Res. 1990 18:5322.

Affiliated with

Also associated with

Rating

Low affinity human IL-12 beta2 receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Low affinity human IL-12 beta2 receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Low affinity human IL-12 beta2 receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-899941