Lotion for FK 506

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514294, A61K 3144

Patent

active

059394277

ABSTRACT:
A lotion comprising a tricyclic compound, typically l!-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo pharmaceutically acceptable salt thereof, a solubilizing and/or absorption-promoting agent, a liquid medium, and optionally an emulsifier and/or a viscosity increasing agent. The lotion is stable, excellent in absorption and has less irritation against the skin and sustained release. Also, the lotion is effective for the treatment and/or prophylaxis of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses.

REFERENCES:
patent: 5260301 (1993-11-01), Nakanishi et al.
patent: 5368865 (1994-11-01), Asakura et al.
patent: 5385907 (1995-01-01), Asakura et al.
patent: 5601844 (1997-02-01), Kagayama et al.

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