Lossless droplet transfer of droplet-based microfluidic...

Measuring and testing – Liquid analysis or analysis of the suspension of solids in a... – Content or effect of a constituent of a liquid mixture

Reexamination Certificate

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C073S061560, C073S061630, C073S064520, C073S863230, C073S863210

Reexamination Certificate

active

08061187

ABSTRACT:
A transfer structure for droplet-based microfluidic analysis is characterized by a first conduit containing a first stream having at least one immiscible droplet of aqueous material and a second conduit containing a second stream comprising an aqueous fluid. The interface between the first conduit and the second conduit can define a plurality of apertures, wherein the apertures are sized to prevent exchange of the first and second streams between conduits while allowing lossless transfer of droplets from the first conduit to the second conduit through contact between the first and second streams.

REFERENCES:
patent: 6278111 (2001-08-01), Sheehan et al.
patent: 2011/0107822 (2011-05-01), Bunner et al.
Kennedy, Robert T., et al., “Rapid Electrophoresis in Parallel for High Throughput Analysis” Symposium Abstract, 23rd International Symposium on Microscale Bioseparations, Feb. 1-5, 2009, Boston, MA.
Roman, Gregory T. , et al., “Sampling and Eletrophoretic Analysis of Segmented Flow Streams Using Virtual Walls in a Microfluidic Device”, Analytical Chemistry, Nov. 1, 2008, 8231-8238 pps., vol. 80, No. 21, ACS Publications, Washington, DC.
Edgar, J. Scott, et al., “Capillary Electrophoresis Separation in the Presence of an Immiscible Boundary for Droplet Analysis,” Analytical Chemistry, Analytical Chemistry, Oct. 1, 2006, 6948-6954 pps., vol. 78, No. 19, ACS Publications, Seattle, WA.

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