Longevity and PAPP-A

Details Longevity and PAPP-A Longevity and PAPP-A

2008-07-22

2008-07-22

Bertoglio, Valarie (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

C800S014000, C800S018000

Reexamination Certificate

active

11093555

ABSTRACT:
This document provides materials and methods related to PAPP-A polypeptides, aging, and transgenic non-human mammals whose genomes comprise a disrupted PAPP-A allele. Methods for making such transgenic non-human mammals, and using them and other mammals to identify and characterize agents that affect conditions related to PAPP-A activity, such as vascular restenosis, atherosclerosis, wound healing, cancer, fibrosis, bone development, fetal development, longevity, and fracture repair, also are provided.

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