Long-wavelength water soluble chlorin photosensitizers useful fo

Details Long-wavelength water soluble chlorin photosensitizers useful fo Long-wavelength water soluble chlorin photosensitizers useful fo

1992-02-24

1994-07-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514410, 540145, A61K 3140, C07D48722

Patent

active

053307410

ABSTRACT:
Novel photosensitizers useful for photodynamic therapy and diagnosis of tumors. Photosensitizers are derived from chlorophyll-a of photosynthetic plants and algae, possess long wavelength absorption between 600 and 800 nm, are stable, and water soluble. A process of preparation of these compounds and method of use for diagnostic and therapeutic purposes.

REFERENCES:
patent: 4675338 (1987-06-01), Bommer et al.
patent: 4693855 (1987-09-01), Bommer et al.
patent: 4977177 (1990-12-01), Bommer et al.
Roberts, W. G., et al., In Vitro Characterization of Monoaspartyl Chlorin e.sub.6 and Diaspartyl Chlorin e.sub.6 for Photodynamic Therapy, J. Nat'l. Can. Inst., 80:330-336(1988).
Hoober, J. K., Photodynamic Sensitizers from Chlorophyll: Purpurin-18 and Chlorin p.sub.6, Photochem. Photobiol., 48:579-582(1988).

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