Long-wavelength fluorescent probe compounds for calcium ions and

Details Long-wavelength fluorescent probe compounds for calcium ions and Long-wavelength fluorescent probe compounds for calcium ions and

1992-12-30

1995-04-25

Warden, Robert J.

Chemistry: analytical and immunological testing

Metal or metal containing

Li, na, k, rb, cs, fr, be, mg, ca, sr, ba, ra

436 63, 436172, 436800, 546170, 548148, 548150, 548180, 549 23, G01N 3352, C07D27762, C07D27770, C07D33504

Patent

active

054098351

ABSTRACT:
Fluorescent, calcium-binding probe compounds having visible-light excitation and emission wavelengths, and a method of usage for these probe compounds in making wavelength-ratiometric or intensity-ratiometric measurements of calcium ion concentration in samples. The probe compounds generally relate to a heterocyclic part as bonded to a Ca.sup.2+ binding unit, namely, BAPTA, via an ethylenically unsaturated group; preferred examples of the heterocyclic group include benzothiazole, naphthothiazole, thiaflavin, indolenine, chloroindolenine, methoxybenzothiazole, and methoxyindolenine.

REFERENCES:
patent: 3660102 (1972-05-01), Riester
patent: 4603209 (1986-07-01), Tsien et al.
patent: 4689432 (1987-08-01), Tsien et al.
patent: 4795712 (1989-01-01), Toner et al.
patent: 4806604 (1989-02-01), Tsien et al.
patent: 4849362 (1989-07-01), DeMarinis et al.
patent: 5049673 (1991-09-01), Tsien et al.
patent: 5085946 (1992-02-01), Saito et al.
patent: 5094958 (1992-03-01), Klainer et al.
patent: 5112960 (1992-05-01), Bronstein et al.
patent: 5141627 (1992-08-01), Tsien et al.
patent: 5212307 (1993-05-01), Wilczak
patent: 5227308 (1993-07-01), Jameson et al.
Gurney, A. M. "Photolabile calcium buffers to selectively activate calcium-dependent processes" Cell. Neuvobiology, 153-77, 1991.
Deng et al. "Synthesis of a new fluorometric calcium ion indicator fura-3 and study on its properties." Huaxne Shiji, 14(1), 40-5, 1992.
Tsien et al. "Control of cytoplasmic calcium with photolabile tetracarboxylate 2-nitrobenzhydrol chelators". Biophysics Journal-50 (5), 843-5, 1986.
Lanza et al. "Increased aggregation and secretion responses of human platelets when loaded . . ." Thromb. Haemostatis, 58 (2), 737-43 1987.
Pethig et al. "On the dissociation constants of BAPTA-type calcium buffers" Cell Calcium, 10 (7), 491-8, 1989.
Zucker, R. S. "Effects of photolabile calcium chelators on fluorescent calcium indicators". Cell Calcium, 13 (1), 29-40, 1992.
Dubinsky, J. M. "Effects of calcium chelators on intracellular calcium and excitotoxicity" Neurosci. Lett., 150 (2), 129-32, 1993.

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