Long wavelength engineered fluorescent proteins

Details Long wavelength engineered fluorescent proteins Long wavelength engineered fluorescent proteins

1997-11-19

2000-06-20

Nashed, Nashaat

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 691, 4352523, 43525233, 43525411, 435410, 4353201, 536 231, 536 235, 530350, C07H 2104, C12N 120, C12N 1500

Patent

active

060777079

ABSTRACT:
This invention provides functional engineered fluorescent proteins with varied fluorescence characteristics that can be easily distinguished from currently existing green and blue fluorescent proteins. In one aspect, the invention provides nucleic acids, expression vectors and recombinant host cells comprising nucleotide sequences encoding functional engineered fluorescent proteins comprising aromatic substitutions at position 66 and a folding mutation. In one embodiment the invention provides for fluorescent proteins containing an aromatic substitution at Thr 203.

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