Long wavelength dyes for infrared tracing

Details Long wavelength dyes for infrared tracing Long wavelength dyes for infrared tracing

1997-05-14

1999-12-21

Mach, D Margaret M

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

252700, 25230116, 25230134, 25230135, 436512, 436528, 436531, 436532, 436533, 436534, 436546, 436172, 436805, 548405, 548524, 548527, 548517, 548539, 548560, 548564, 549 60, 549 61, 549 62, 549 70, 549 73, 549473, 549474, 549475, 549483, 549 59, 546257, 546262, 5462791, 5462804, 5462847, 5462834, 546314, 546340, 568325, 568328, 568331, 568332, 568333, C09K 300, C09K 1106, C09K 1102, G01N 33546

Patent

active

060051132

ABSTRACT:
The invention relates to fluorescent dyes that are substituted or unsubstituted derivatives of 1-(isoindolyl)methylene-isoindole that are bound through both isoindole nitrogens to a boron difluoride moiety, forming a fluorescent dibenzopyrrometheneboron difluoride compound ##STR1## that is further substituted by bathochromic substituents that are aryl or heteroaryl moieties further substituted by an additional aryl or heteroaryl, that is itself optionally further substituted by an additional aryl or heteroaryl. These aryl and heteroaryl groups are separated by a covalent bond, or by an ethenyl, butadienyl or hexatrienyl linkage. The dyes of the invention are particularly useful as labels for carriers, particularly polymeric microparticles. The resulting microparticles have a long-wavelength fluorescence emission, and possess utility for tracing flow in biological systems, particularly in tracing blood flow.

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