Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1993-04-08
1995-09-19
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
530350, 5303911, 5303913, 5303915, 530402, 530405, 536 221, 548110, 548405, 544229, 546 13, 372 53, 372 54, C07K 1700, C07K 1600, C07K 1400, C07H 1900
Patent
active
054516633
ABSTRACT:
This invention relates to derivatives of dipyrrometheneboron difluoride fluorescent dyes that have an absorption maximum at wavelengths longer than about 525 nm, and are chemically reactive with nucleic acids, proteins, carbohydrates, and other biologically derived or synthetic chemical materials to form dye-conjugates. The dye-conjugates generally have the structure: ##STR1## wherein at least one of the substituents R.sub.1 -R.sub.7, covalently bonds to a specific binding pair member, and further where at least one of the substituents R.sub.1 -R.sub.7 contains a bathochromic moiety that is heteroaryl or alkenyl. The remaining substituents, which may be the same or different, are hydrogen, halogen, alkyl (containing 1-5 carbon atoms), aryl, arylalkyl, or sulfo.
REFERENCES:
patent: 4774339 (1988-09-01), Haugland et al.
patent: 4916711 (1990-04-01), Boyer et al.
patent: 5106951 (1992-04-01), Morgan et al.
patent: 5187288 (1993-02-01), Kang et al.
patent: 5248782 (1993-09-01), Haugland et al.
Kalofonos et al., The Journal of Nuclear Medicine, vol. 31, No. 11, pp. 1791-1796 (1990).
Wories et al., A novel water-soluble fluorescent probe: Synthesis, luminescence and biological properties of the sodium salt of the 4-sulfonato-3,3', 5'5-tetramethyl-2,2'-pyrromethen-1,1'-BF.sub.2 complex, Recl. Trav. Chim. PAYSBAS 104, 288 (1985).
Pavlopoulos et al., Laser action from a tetramethylpyrromethene-BF.sub.2 complex, App. Optics 27, 4998 (1988).
Demas et al., The Measurement of Photoluminescence Quantum Yields J. Phys. Chem 75, 991 (1971).
Kruse et al., New Methods for the Synthesis of 2-Arylpyrroles, Heterocycles 26, 3141 (1987).
Rapoport et al., 2,2'-Bipyrrole, J. Am. Chem. Soc. 84, 2178 (1962).
Bullock et al., A Synthesis of Coproporphyrin, J. Chem. Soc. 1430 (1958).
R. M. Silverstein, et al., 2-Pyrrolealdehyde, Org. Synth. Coll. vol. IV, p. 831.
Falk et al., Monatshefte fur Chemie, 110, 987 (1979).
Falk et al., Monatshefte fur Chemie, 121, 67 (1990).
Boyer et al., Laser action from 2,6,8-trisubstituted 1,3,5,7-tetramethyl-pyrromethene-BF.sub.2 complexes: part 2, Applied Optics 30, 3788 (1991).
Waldmann, Science, vol. 252, pp. 1657-1662 (1991).
Borrebaeck, Journal of Immunological Methods, vol. 123, pp. 157-165 (1989).
Haugland Richard P.
Kang Hee C.
Chan Christina Y.
Helfenstein Allegra J.
Molecular Probes, Inc.
Skaugset Anton E.
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