Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1994-05-23
1997-01-07
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540145, 540474, C07D48722
Patent
active
055918476
ABSTRACT:
Compounds having utility as light absorbing compounds, especially in the area of photodynamic therapy.
Such compounds have the formula: ##STR1## where Z is .dbd.O or .dbd.NR.sub.6, where R.sub.6 is lower alkyl of from 1 to 8 carbon atoms or ##STR2## R.sub.1 is ##STR3## where R.sub.7 is ##STR4## or --ORS, where R.sub.8 is hydrogen or lower alkyl of 1 to 8 carbon atoms, or R.sub.7 is an amino acid residue connected at a nitrogen atom of such residue; R.sub.2 is lower alkyl or lower alkylene of from 2 to 4 carbon atoms or a formal or carbonyl containing group of from 1 to 4 carbon atoms; R.sub.3 and R.sub.4 are --H or --OR.sub.8 or are joined together so that each represents one-half of a chemical bond and R.sub.4 may be taken together with R.sub.5 to form .dbd.O; and R.sub.5 is ethyl or is taken together with R.sub.4 to form .dbd.O; provided that when Z is --O-- the sum of the number of carbon atoms in R.sub.1 through R.sub.5 is from 12 to 20 and when Z is .dbd.NR.sub.6, the sum of the number of carbon atoms in R.sub.1 through R.sub.6 is 8 to 20.
REFERENCES:
Lee et al., J. Chem. Soc. Perkin I (19) pp. 2369-2377; 1993.
Chang et al., J. Chem. Soc., Chem. Commun. pp. 1213-1215; 1986.
Dougherty Thomas J.
Pandey Ravindra K.
Shiau Fuu-Yau
Smith Kevin M.
Dunn Michael L.
Health Research , Inc.
Shah Mukund J.
Sripada Pavanaram K.
The Regents of the University of California
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