Long term storage of red cells in unfrozen solution

Details Long term storage of red cells in unfrozen solution Long term storage of red cells in unfrozen solution

1995-03-24

1997-02-11

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

424529, 424533, A01N 102, A61K 3514, A61K 3518

Patent

active

056019726

ABSTRACT:
A method for prolonging storage shelf-life of red blood cells under refrigerated conditions includes separating plasma from the red blood cells while retaining residual plasma and adding a biologically compatible solution having an effective osmolality of less than 70 mOsm to the red blood cells. The biologically compatible solution preferably includes at least one penetrating solute that penetrates red cells more slowly than water and substantially no non-penetrating anions and non-penetrating non-electrolytes.

REFERENCES:
patent: 4061537 (1977-12-01), Seiler et al.
patent: 4585735 (1986-04-01), Meryman et al.
patent: 5250303 (1993-10-01), Meryman et al.
Law, P., Cryopreservation of Platelets: Current Status, Plasma Ther Transfus Technol 1982 3: 317-326.
H. T. Meryman, "Influence of certain neutral solutes on red cell membrane area and permeability during hypotonic stress," American Journal of Physiology, vol.225, No.2, Aug. 1973.

Affiliated with

Also associated with

Rating

Long term storage of red cells in unfrozen solution does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Long term storage of red cells in unfrozen solution, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Long term storage of red cells in unfrozen solution will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-340968