Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1990-01-10
1991-09-03
Rosenbaum, C. Fred
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
424438, A23K 118
Patent
active
050450824
ABSTRACT:
The invention provides a long-term dispensing device comprising a first agent delivery means for short-term and continuous delivery of agent, retained together with a second agent delivery means capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (1) a short term delivery means for rapid and continuous delivery of agent to the environment of use; and (2) a long-term delivery means comprising a semipermeable wall which surrounds and defines an internal lumen; a means in the lumen for expanding and occupying an increased volume of the lumen; a beneficial agent in the lumen that provides a dispensable formulation to the environment of use; and a means in the device for delivery of the beneficial agent to the environment of use over time.
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Ayer Atul D.
Eckenhoff James B.
Kuczynski Anthony L.
Wright Jeremy C.
ALZA Corporation
Finkel Sharon
Larson Jacqueline S.
Mandell Edward L.
Rosenbaum C. Fred
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